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首页> 外文期刊>American Journal of Physiology >Airway hyperresponsiveness induced by cationic proteins in vivo: site of action.
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Airway hyperresponsiveness induced by cationic proteins in vivo: site of action.

机译：体内阳离子蛋白诱导的气道高反应性：作用部位。

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摘要

Major basic protein and other native cationic proteins increase airway hyperresponsiveness when administered to the luminal surface of the airways in vitro. To determine whether the same applies in vivo, we assessed airway responsiveness in rats challenged with both aerosolized and intravenously infused methacholine. We partitioned total lung resistance into its airway and tissue components using the alveolar capsule technique. Neither poly-l-lysine nor major basic protein altered baseline mechanics or its dependence on positive end-expiratory pressures ranging from 1 to 13 cmH(2)O. When methacholine was administered to the lungs as an aerosol, both cationic proteins increased responsiveness as measured by airway resistance, tissue resistance, and tissue elastance. However, responsiveness of all three parameters was unchanged when the methacholine was infused. Together, these findings suggest that cationic proteins alter airway responsiveness in vivo by an effect that is apparently limited to the bronchial epithelium.
机译：当主要的碱性蛋白和其他天然阳离子蛋白在体外施用于气道腔表面时，会增加气道高反应性。为了确定在体内是否同样适用，我们评估了在雾化和静脉内注射乙酰甲胆碱的大鼠中的气道反应性。我们使用肺泡囊技术将总肺阻力分为其气道和组织成分。聚l赖氨酸或主要的基本蛋白质都不会改变基线力学或其对1到13 cmH（2）O范围内的呼气末正压的依赖性。当将乙酰甲胆碱以气雾剂形式施用于肺部时，两种阳离子蛋白均可通过气道阻力，组织阻力和组织弹性来提高响应速度。但是，当注入乙酰甲胆碱时，所有三个参数的响应性均未改变。总之，这些发现表明阳离子蛋白通过明显限于支气管上皮的作用改变了体内的气道反应性。

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