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首页> 外文期刊>American Journal of Physiology >Temporal dynamics of late-night photic stimulation of the human circadian timing system.
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Temporal dynamics of late-night photic stimulation of the human circadian timing system.

机译：人类昼夜节律定时系统的深夜光刺激的时间动态。

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摘要

The light-dark cycle is the primary synchronizing factor that keeps the internal circadian pacemaker appropriately aligned with the environmental 24-h day. Although it is known that ocular light exposure can effectively shift the human circadian pacemaker and do so in an intensity-dependent manner, the curve that describes the relationship between light intensity and pacemaker response has not been fully characterized for light exposure in the late biological night. We exposed subjects to 3 consecutive days of 5 h of experimental light, centered 1.5 h after the timing of the fitted minimum of core body temperature, and show that such light can phase advance shift the human circadian pacemaker in an intensity-dependent manner, with a logistic model best describing the relationship between light intensity and phase shift. A similar sigmoidal relationship is also observed between light intensity and the suppression of plasma melatonin concentrations that occurs during the experimental light exposure. As with a simpler, 1-day light exposure during the early biological night, our data indicate that the human circadian pacemaker is highly sensitive even to typical room light intensities during the late biological night, with approximately 100 lux evoking half of the effects observed with light 10 times as bright.
机译：光暗周期是保持内部昼夜节律起搏器与环境全天24小时保持一致的主要同步因素。尽管已知眼部曝光可以有效地改变人体生物钟起搏器并以强度依赖的方式移动，但是描述光强度与心脏起搏器反应之间关系的曲线并未在生物晚间的曝光中得到充分表征。 。我们将受试者连续5天连续3天暴露于实验光中，在达到最低核心体温的时间之后1.5小时居中，并显示这种光可以使人的昼夜节律起搏器以强度依赖的方式相移。一个能最好地描述光强度和相移之间关系的逻辑模型。在光强度和实验性曝光期间发生的血浆褪黑激素浓度抑制之间也观察到类似的S型关系。与在生物晚间较简单的1天光照一样，我们的数据表明，即使在生物晚间，人体昼夜节律起搏器对典型的室内光线强度也高度敏感，大约有100 lux的光通量引起了这种现象。亮度是亮度的10倍。

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