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首页> 外文期刊>American Journal of Physiology >Altered autonomic cardiac regulation in individuals with Down syndrome.
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Altered autonomic cardiac regulation in individuals with Down syndrome.

机译：唐氏综合症患者的自主心脏调节改变。

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We tested the hypothesis that individuals with Down syndrome, but without congenital heart disease, exhibit altered autonomic cardiac regulation. Ten subjects with Down syndrome (DS) and ten gender-and age-matched healthy control subjects were studied at rest and during active orthostatism, which induces reciprocal changes in sympathetic and parasympathetic traffic to the heart. Autoregressive power spectral analysis was used to investigate R-R interval variability. Baroreflex modulation of sinus node was assessed by the spontaneous baroreflex sequences method. No significant differences between DS and control subjects were observed in arterial blood pressure at rest or in response to standing. Also, R-R interval did not differ at rest. R-R interval decreased significantly less during standing in DS vs. control subjects. Low-frequency (LFNU) and high-frequency (HFNU) (both expressed in normalized units) components of R-R interval variability did not differ between DS and control subjects at rest. During standing, significant increase in LFNU and decrease in HFNU were observed in control subjects but not in DS subjects. Baroreflex sensitivity (BRS) did not differ between DS and control subjects at rest and underwent significant decrease on going from supine to upright in both groups. However, BRS was greater in DS vs. control subjects during standing. These data indicate that subjects with DS exhibit reduced HR response to orthostatic stress associated with blunted sympathetic activation and vagal withdrawal and with a lesser reduction in BRS in response to active orthostatism. These findings suggest overall impairment in autonomic cardiac regulation in DS and may help to explain the chronotropic incompetence typically reported during exercise in subjects with DS without congenital heart disease.
机译：我们检验了唐氏综合症但没有先天性心脏病的个体表现出自主心脏调节改变的假设。研究了十名患有唐氏综合症（DS）的受试者以及十名性别和年龄相匹配的健康对照受试者，这些受试者在休息和主动矫形时均处于活动状态，这会导致对心脏的交感神经和副交感神经的交互变化。自回归功率谱分析用于研究R-R区间的变异性。通过自发的压力反射序列法评估窦房结的压力反射调节。在静息或站立时的动脉血压方面，DS与对照组之间无显着差异。同样，R-R间隔在静止时也没有差异。与对照组相比，DS站立时的R-R间隔减少明显更少。 DS和静止受试者的R-R间隔变异性的低频（LFNU）和高频（HFNU）（均以标准化单位表示）没有差异。在站立期间，在对照受试者中观察到LFNU显着增加而在HFNU中观察到降低，而在DS受试者中则未观察到。 DS和静息对照组之间的压力反射敏感性（BRS）没有差异，并且两组从仰卧到直立的经历都显着降低。然而，站立期间，DS组的BRS高于对照组。这些数据表明，DS受试者对与直交交感神经激活和迷走神经退缩相关的体位压力的HR反应降低，而对活动性立位状态的反应的BRS降低较少。这些发现表明DS中自主神经调节的整体障碍，并且可能有助于解释在患有先天性心脏病的DS患者运动期间通常报道的变时能力不足。

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