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首页> 外文期刊>American Journal of Physiology >Delta-opioid receptor agonist reduces severity of postresuscitation myocardial dysfunction.
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Delta-opioid receptor agonist reduces severity of postresuscitation myocardial dysfunction.

机译：δ阿片受体激动剂可降低复苏后心肌功能障碍的严重程度。

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摘要

Postresuscitation myocardial dysfunction is recognized as a leading cause of early death after initially successful cardiopulmonary resuscitation (CPR). In the present study, we hypothesized that a delta-opioid receptor agonist would decrease the severity of postresuscitation myocardial dysfunction and improve survival. Fifteen Sprague-Dawley rats, fasted overnight with access to water, were anesthetized by an injection of 45 mg/kg ip pentobarbital sodium. Additional doses of 10 mg/kg were administered at hourly intervals but not within 30 min before induced ventricular fibrillation (VF). Either the delta-opioid receptor agonist pentazocine (300 microg/kg), pentazocine pretreated with the opioid receptor-blocking agent naloxone (1 mg/kg), or saline placebo was injected into the right atrium after 5 min of untreated VF and 3 min before initiation of CPR. After an additional 8 min of CPR administration, defibrillation was attempted. All animals were successfully resuscitated. Left ventricular rate of pressure increase at 40 mmHg and cardiac index values were significantly improved in pentazocine-treated animals, which also had significantly longer survival times (60 +/- 11 vs. 16 +/- 7 h; P < 0.01). Except for ease of defibrillation, the beneficial effects of pentazocine were completely abolished by pretreatment with naloxone. The concept of pharmacological hibernation employing a delta-opioid receptor agonist is a novel and promising intervention for minimizing global ischemic injury during CPR and postresuscitation myocardial dysfunction.
机译：复苏后心肌功能障碍被认为是最初成功的心肺复苏（CPR）后早期死亡的主要原因。在本研究中，我们假设δ​​阿片受体激动剂会降低复苏后心肌功能障碍的严重程度并提高生存率。通过注射45mg / kg腹膜内戊巴比妥钠麻醉15只Sprague-Dawley大鼠，使其禁食过夜，并用水。在诱发心室纤颤（VF）之前，应每小时间隔一次，但不要在30分钟内给予10 mg / kg的额外剂量。在未经治疗的VF 5分钟和3分钟后，将右旋心房注射δ-阿片受体激动剂喷他佐辛（300 microg / kg），用阿片受体阻滞剂纳洛酮（1 mg / kg）预处理的喷他佐辛或盐水安慰剂。在进行心肺复苏术之前。心肺复苏再加8分钟后，尝试除颤。所有动物均成功复苏。在喷他佐辛治疗的动物中，左心室压力增加40 mmHg时心率指数和心脏指数值显着改善，它们的生存时间也明显更长（60 +/- 11 vs. 16 +/- 7 h; P <0.01）。除易于除纤颤外，用纳洛酮预处理可完全消除喷他佐辛的有益作用。使用δ阿片类受体激动剂进行药理学冬眠的概念是一种新颖且有希望的干预措施，可最大程度地减少CPR和复苏后心肌功能障碍期间的整体缺血损伤。

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