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首页> 外文期刊>American Journal of Physiology >Nocturnal hemodialysis is associated with restoration of impaired endothelial progenitor cell biology in end-stage renal disease.
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Nocturnal hemodialysis is associated with restoration of impaired endothelial progenitor cell biology in end-stage renal disease.

机译：夜间血液透析与终末期肾脏疾病中受损的内皮祖细胞生物学功能的恢复有关。

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摘要

Cardiovascular disease is the principal cause of death in end-stage renal disease (ESRD) patients. Endothelial progenitor cells (EPCs) play a critical role in vascular repair, and improving EPC biology represents a novel therapeutic target. Three groups of age- and gender-matched patients were studied: 1) 10 healthy control, 2) 12 conventional hemodialysis (CHD) patients, and 3) 10 nocturnal hemodialysis (NHD) patients. EPC number and migratory function were assessed. Left ventricular mass index (LVMI) was derived, and correlations between EPC biology, uremic clearance, and LVMI were made. Compared with controls, EPC number and function were markedly impaired in CHD patients [(3.48 +/- 1.2 vs. 0.86 +/- 0.20%/50,000 cells, P < 0.05) and (18.8 +/- 2.64 vs. 3.75 +/- 0.34 cells/high-power field, P < 0.05), respectively]. In contrast, EPC number and function were normal in NHD patients [(3.48 +/- 1.17 vs. 3.83 +/- 0.77%/50,000 cells) and (18.8 +/- 2.6 vs. 22.2 +/- 2.4 cells/high-power field), respectively].Among ESRD patients, EPC number and function inversely correlated with predialysis urea concentration (r = -0.40; r = -0.57), LVMI (r = -0.41; -0.46) and systolic BP (r = -0.58; r = -0.44). We demonstrate that NHD is associated with restoration of abnormal EPC biology in ESRD. Given the increasing importance of EPCs in the repair and restoration of cardiovascular function, these data have important clinical implications for vascular risk in ESRD patients.
机译：心血管疾病是终末期肾脏疾病（ESRD）患者的主要死亡原因。内皮祖细胞（EPC）在血管修复中起着关键作用，改善EPC生物学代表了一种新的治疗靶点。研究了三组年龄和性别匹配的患者：1）10名健康对照者，2）12例常规血液透析（CHD）患者，和3）10例夜间血液透析（NHD）患者。评估了EPC数量和迁移功能。得出左心室质量指数（LVMI），并进行EPC生物学，尿毒症清除率和LVMI之间的相关性。与对照组相比，冠心病患者的EPC数量和功能明显受损[（3.48 +/- 1.2对0.86 +/- 0.20％/ 50,000细胞，P <0.05）和（18.8 +/- 2.64对3.75 +/- 0.34个细胞/大功率场，P <0.05）]。相反，NHD患者的EPC数量和功能正常（（3.48 +/- 1.17比3.83 +/- 0.77％/ 50,000个细胞）和（18.8 +/- 2.6比22.2 +/- 2.4个/高功率）在ESRD患者中，EPC数量和功能与透析前尿素浓度（r = -0.40; r = -0.57），LVMI（r = -0.41; -0.46）和收缩压（r = -0.58）成反比。 ; r = -0.44）。我们证明NHD与ESRD中异常EPC生物学的恢复有关。鉴于EPC在修复和恢复心血管功能中的重要性日益提高，这些数据对于ESRD患者的血管风险具有重要的临床意义。

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