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首页> 外文期刊>American Journal of Physiology >Chronic estradiol and progesterone treatment in conscious dogs: effects on insulin sensitivity and response to hypoglycemia.
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Chronic estradiol and progesterone treatment in conscious dogs: effects on insulin sensitivity and response to hypoglycemia.

机译：清醒犬的慢性雌二醇和孕酮治疗：对胰岛素敏感性和对低血糖反应的影响。

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We evaluated the effect of chronic (3 wk) subcutaneous treatment with progesterone and estradiol (PE; producing serum levels observed in the 3rd trimester of pregnancy) or placebo (C) on hepatic and whole body insulin sensitivity and response to hypoglycemia in conscious, overnight-fasted nonpregnant female dogs, using tracer and arteriovenous difference techniques. Insulin was infused peripherally for 3 h at 1.8 mU x kg(-1) x min(-1). Glucose was allowed to fall to 3 mM (Hypo) or maintained at 6 mM (Eugly) by peripheral glucose infusion. Insulin concentrations were significantly higher in Eugly-PE (n = 7) and Hypo-PE (n = 7) than in Eugly-C (n = 6) and Hypo-C groups (n = 7), but there were no significant differences in hepatic insulin extraction. Concentrations of glucagon, cortisol, epinephrine, and norepinephrine did not differ significantly between Eugly groups or between Hypo groups. Whole body glucose disposal, adjusted for the differences in insulin between groups, was 35% higher in Eugly-C vs. Eugly-PE groups (P < 0.05). Eugly-C and Eugly-PE groups exhibited similar rates of net hepatic glucose uptake, but the rate of glucose appearance was greater in Eugly-PE in the last hour (P < 0.05). Net hepatic glucose output was greater (P < 0.05) in Hypo-PE than in Hypo-C groups, and the glucose infusion rate required to maintain equivalent hypoglycemia was less (P < 0.05). The rate of gluconeogenic flux did not differ between Hypo groups. Chronic progesterone and estradiol exposure caused whole body (primarily skeletal muscle) insulin resistance and enhanced the liver's response to hypoglycemia without altering counterregulatory hormone concentrations.
机译：我们评估了孕酮和雌二醇（PE;在妊娠的第三个中期观察到的血清水平）或安慰剂（C）的慢性（3周）皮下治疗对肝脏和全身胰岛素敏感性以及对有意识的，过夜的低血糖反应的影响-使用示踪剂和动静脉差异技术禁食非怀孕雌性狗。在1.8 mU x kg（-1）x min（-1）周围注入胰岛素3小时。通过外周葡萄糖输注使葡萄糖降至3 mM（Hypo）或维持在6 mM（Eugly）。 Eugly-PE（n = 7）和Hypo-PE（n = 7）的胰岛素浓度显着高于Eugly-C（n = 6）和Hypo-C组（n = 7），但无显着差异在肝胰岛素提取中。在Eugly组或Hypo组之间，胰高血糖素，皮质醇，肾上腺素和去甲肾上腺素的浓度没有显着差异。调整了两组之间的胰岛素差异后，Eugly-C组的全身葡萄糖处置量比Eugly-PE组高了35％（P <0.05）。 Eugly-C和Eugly-PE组的净肝葡萄糖摄取率相似，但最近一小时Eugly-PE中的葡萄糖出现率更高（P <0.05）。 Hypo-PE组的净肝葡萄糖输出量大于Hypo-C组（P <0.05），维持等效低血糖所需的葡萄糖输注速率也较低（P <0.05）。 Hypo组之间的糖异生通量率没有差异。慢性孕酮和雌二醇的暴露引起全身（主要是骨骼肌）胰岛素抵抗，并增强肝脏对低血糖的反应，而不会改变调节激素的浓度。

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