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首页> 外文期刊>American Journal of Physiology >Effects of chronic baroreceptor unloading on blood pressure in the dog.
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Effects of chronic baroreceptor unloading on blood pressure in the dog.

机译：慢性压力感受器卸载对狗血压的影响。

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We have developed a new model of chronic baroreceptor unloading (CBU) in the dog. Initial characterization of the model indicated that CBU increased mean arterial pressure (MAP) by an average of 22 mmHg for 7 days. The goal of the present study was to replicate the previous study using telemetry to record MAP continuously and to determine the effects of CBU (n = 7) on chronic regulation of MAP. We also prepared a group of dogs with sinoaortic denervation (SAD, n = 6) to compare the time course of changes in MAP in the two models. Control levels (7 day average +/- SE) of MAP in the CBU and SAD groups were 94 +/- 2 and 94 +/- 1 mmHg, respectively. MAP averaged 124 +/- 8 and 103 +/- 4 mmHg during the first and second weeks after SAD (both P < 0.05) and then declined to levels not different from control during weeks 3-5. In the CBU group, MAP averaged 120 +/- 4 mmHg during the first week, declined to 111 +/- 4 mmHg during the second week, and stabilized at 104 mmHg during weeks 3-5 (all P < 0.05 compared with control). Plasma norepinephrine levels were increased significantly for the first week after SAD and for 2 wk after CBU but were not different from control for the remainder of the study. These results indicate that the initial increase in MAP after CBU is not sustained but declines to a level that is modestly higher than control. However, because MAP did not fall to control levels, the results are compatible with the hypothesis that baroreceptor input can influence the long-term level of MAP.
机译：我们已经开发了犬慢性压力感受器卸载（CBU）的新模型。该模型的初始特征表明CBU在7天内平均提高了22 mmHg的平均动脉压（MAP）。本研究的目的是复制遥测技术以连续记录MAP并确定CBU（n = 7）对MAP慢性调节的影响。我们还准备了一组患有窦主动脉去神经支配的狗（SAD，n = 6），以比较两种模型中MAP变化的时程。 CBU和SAD组的MAP对照水平（7天平均+/- SE）分别为94 +/- 2和94 +/- 1 mmHg。在SAD后的第一周和第二周，MAP平均为124 +/- 8和103 +/- 4 mmHg（均P <0.05），然后在3-5周内降至与对照组无差异的水平。在CBU组中，第一周的MAP平均为120 +/- 4 mmHg，第二周下降至111 +/- 4 mmHg，并在3-5周稳定在104 mmHg（与对照组相比，所有P <0.05） 。 SAD后第一周和CBU后2周血浆去甲肾上腺素水平显着增加，但在其余研究中与对照组无差异。这些结果表明，CBU后MAP的最初增加并没有持续，但下降到比对照组稍高的水平。但是，由于MAP并未降至控制水平，因此该结果与压力感受器输入可影响MAP长期水平的假设相吻合。

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