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首页> 外文期刊>American Journal of Physiology >Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates.
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Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates.

机译：酸和胃微粒的吸入引起的急性炎症性肺损伤中的表面活性剂改变。

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This study examines surfactant dysfunction in rats with inflammatory lung injury from intratracheal instillation of hydrochloric acid (ACID, pH 1.25), small nonacidified gastric particles (SNAP), or combined acid and small gastric particles (CASP). Rats given CASP had the most severe lung injury at 6, 24, and 48 h based on decreases in arterial oxygenation and increases in erythrocytes, total leukocytes, neutrophils, total protein, and albumin in bronchoalveolar lavage (BAL). The content of large surfactant aggregates in BAL was reduced in all forms of aspiration injury, but decreases were greatest in rats given CASP. Large aggregates from aspiration-injured rats also had decreased levels of phosphatidylcholine (PC) and increased levels of lyso-PC and total protein compared with saline controls (abnormalities for CASP were greater than for SNAP or ACID alone). The surface tension-lowering ability of large surfactant aggregates on a bubble surfactometer was impaired in rats with aspiration injury at 6, 24, and 48 h, with the largest activity reductions found in animals given CASP. There were strong statistical correlations between surfactant dysfunction (increased minimum surface tension and reduced large aggregate content) and the severity of lung injury based on arterial oxygenation and levels of albumin, protein, and erythrocytes in BAL (P < 0.0001). Surfactant dysfunction also correlated strongly with reduced lung volumes during inflation and deflation (P = 0.0004-0.005). These results indicate that surfactant abnormalities are functionally important in gastric aspiration lung injury and contribute significantly to the increased severity of injury found in CASP compared with ACID or SNAP alone.
机译：这项研究检查了气管内滴注盐酸（ACID，pH 1.25），小的非酸化胃小颗粒（SNAP）或酸和小胃小颗粒混合（CASP）引起的炎症性肺损伤大鼠的表面活性剂功能障碍。接受CASP的大鼠在6、24和48 h时肺部损伤最严重，这是由于支气管肺泡灌洗（BAL）中的氧合减少，红细胞，总白细胞，中性粒细胞，总蛋白和白蛋白增加所致。在各种形式的吸入性损伤中，BAL中大型表面活性剂聚集体的含量均降低，但在给予CASP的大鼠中，降幅最大。与盐水对照组相比，吸入性损伤大鼠的大聚集体的磷脂酰胆碱（PC）水平降低，溶血PC和总蛋白水平升高（CASP异常大于单独SNAP或ACID）。在6、24和48 h有抽吸损伤的大鼠中，气泡表面张力计上的大型表面活性剂聚集体的降低表面张力的能力受到损害，在给予CASP的动物中发现最大的活性降低。表面活性剂功能障碍（增加的最小表面张力和减少的大量骨料含量）与肺损伤的严重程度之间存在很强的统计相关性（基于BAL中的动脉氧合和白蛋白，蛋白质和红细胞的水平）（P <0.0001）。在充气和放气期间，表面活性剂功能障碍也与肺容量减少密切相关（P = 0.0004-0.005）。这些结果表明，与单独使用ACID或SNAP相比，表面活性剂异常在胃部吸入性肺损伤中具有重要的功能，并且对CASP中发现的损伤严重程度有明显贡献。

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