• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Role of endothelin in mediating postmenopausal hypertension in a rat model.
【24h】

Role of endothelin in mediating postmenopausal hypertension in a rat model.

机译：内皮素在介导大鼠绝经后高血压中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cardiovascular disease is the leading cause of death in women after menopause. Hypertension, a major cardiovascular risk factor, becomes more prevalent after menopause. The mechanisms responsible for the increase in blood pressure (BP) in postmenopausal women are unknown. We have recently characterized the aged, postestrous-cycling (PMR) spontaneously hypertensive rats (SHR) as a model of postmenopausal hypertension. The purpose of the present study was to determine whether endothelin plays a role in the increased BP in PMR. Premenopausal female SHR, aged 4-5 mo (YF), and PMR, aged 16 mo, were studied. Expression of preproendothelin-1 mRNA was not different in either renal cortex or medulla between PMR and YF (n = 7-8/group). In contrast, ET-1 peptide expression was significantly higher in renal cortex of PMR than in renal cortex of YF, but there was no difference in medullary ET-1. Expression of endothelin ET(A) receptor (ET(A)R) mRNA was lower in renal cortex and medulla of PMR than of YF. Additionalgroups of rats (n = 6-7/group) were treated for 3 wk with the ET(A)R antagonist ABT-627 (5 mg.kg(-1).day(-1)). BP was significantly higher in PMR than in YF. ET(A)R antagonist reduced BP in PMR by 20% to the level found in control YF. ET(A)R antagonist had no effect on BP in YF. These data support the hypothesis that the increase in BP in PMR is mediated in part by endothelin and the ET(A)R.
机译：心血管疾病是绝经后女性死亡的主要原因。高血压是心血管的主要危险因素，在绝经后更为普遍。绝经后女性血压升高的机制尚不清楚。我们最近已将老年的发情后骑自行车（PMR）自发性高血压大鼠（SHR）表征为绝经后高血压的模型。本研究的目的是确定内皮素是否在PMR的BP升高中起作用。研究了4-5月龄（YF）的绝经前女性SHR和16月龄的PMR。在PMR和YF之间，肾上腺皮质或髓质中前原内皮素-1 mRNA的表达没有差异（n = 7-8 /组）。相反，PMR肾皮质中的ET-1肽表达明显高于YF肾皮质中的表达，但髓质ET-1没有差异。内皮素ET（A）受体（ET（A）R）mRNA在PMR的肾皮质和延髓中的表达低于YF。用ET（A）R拮抗剂ABT-627（5 mg.kg（-1）.day（-1））治疗其他组的大鼠（n = 6-7 /组）3周。 PMR中的BP明显高于YF。 ET（A）R拮抗剂可将PMR中的BP降低20％，达到对照YF中的水平。 ET（A）R拮抗剂对YF中的BP无影响。这些数据支持以下假设：PMR中的BP升高部分由内皮素和ET（A）R介导。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号