• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution.
【24h】

Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution.

机译：在极端的血液稀释过程中，藻酸盐血浆扩展剂可保持灌注和血浆粘度。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Extreme hemodilution was performed in the hamster chamber window model using 6% Dextran 70, lowering systemic hematocrit by 60%. Animals were subsequently divided into three groups and hemodiluted to a hematocrit of 11% using 6% Dextran 70, 6% Dextran 500, and a 4% Dextran 70 + 0.7% alginate solution (n = 6 each group). Final plasma viscosities were 1.4 +/- 0.2, 2.2 +/- 0.1, and 2.7 +/- 0.2 cp, respectively, (P < 0.05, high viscosity vs. low viscosity). Blood viscosities were 2.1 +/- 0.2, 2.9 +/- 0.4, and 3.9 +/- 0.3 cp, respectively. The lowest blood and plasma viscosity group had a significantly lower functional capillary density, 37 +/- 16%, whereas the two high-viscosity solutions were 71 +/- 15% and 76 +/- 12% (P < 0.05, high viscosity vs. low viscosity), respectively. Arteriolar and venular flow in the Dextran 500 and alginate groups was higher than baseline (i.e., normal nontreated animals), whereas the low-viscosity group showed a reduction in flow. These microvascular changes were paralleled by changes in base excess, which was negative for the Dextran 70 group and positive for the other groups. However, tissue Po(2) was uniformly low for all groups (average of 1.4 mmHg). Calculation of tissue oxygen consumption in the window chamber based on the microvascular data, flow, and intravascular Po(2) showed that only the alginate + Dextran 70 solution-exchanged animals returned to baseline oxygen consumption, whereas the other groups were lower than baseline (P < 0.05). These results show that hemodilution performed with high-viscosity plasma expanders yields systemic arterial pressures and functional capillary densities that are significantly higher (P < 0.05) than those obtained with 6% Dextran 70, a fluid whose viscosity is similar to that of plasma. A condition for obtaining these results is that the oncotic pressure of the plasma expander be titrated to near normal, so that autotransfusion of fluid from the tissue into the vascular compartment does not reduce the effects of increasing plasma viscosity and increased shear stress on the microvascular wall.
机译：在仓鼠窗模型中使用6％的Dextran 70进行了极端的血液稀释，从而使全身血细胞比容降低了60％。随后将动物分为三组，并使用6％的Dextran 70、6％的Dextran 500和4％的Dextran 70 + 0.7％藻酸盐溶液将其血液稀释至11％的血细胞比容（每组n = 6）。最终血浆粘度分别为1.4 +/- 0.2、2.2 +/- 0.1和2.7 +/- 0.2 cp（P <0.05，高粘度与低粘度）。血液粘度分别为2.1 +/- 0.2、2.9 +/- 0.4和3.9 +/- 0.3cp。最低的血液和血浆粘度组的功能性毛细血管密度显着较低，为37 +/- 16％，而两种高粘度溶液分别为71 +/- 15％和76 +/- 12％（P <0.05，高粘度相对于低粘度）。 Dextran 500和藻酸盐组的小动脉和小静脉流量高于基线（即正常未处理的动物），而低粘度组显示流量减少。这些微血管变化与碱基过量的变化平行，Dextran 70组为阴性，其他组为阳性。但是，所有组的组织Po（2）均较低（平均1.4 mmHg）。根据微血管数据，流量和血管内Po（2）计算窗室中的组织耗氧量显示，只有藻酸盐+右旋糖酐70溶液交换的动物恢复到基线耗氧量，而其他组低于基线耗氧量（ P <0.05）。这些结果表明，使用高粘度血浆膨胀剂进行血液稀释所产生的全身动脉压和功能性毛细血管密度明显高于使用6％右旋糖酐70（一种粘度与血浆相似的流体）所获得的血液密度和功能性毛细血管密度（P <0.05）。获得这些结果的条件是血浆扩张器的渗透压被滴定至接近正常，从而使流体从组织向血管腔的自输不会降低血浆粘度增加和微血管壁剪切应力增加的影响。 。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号