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首页> 外文期刊>American Journal of Physiology >Renal vascular response to static handgrip exercise: sympathetic vs. autoregulatory control.
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Renal vascular response to static handgrip exercise: sympathetic vs. autoregulatory control.

机译：静态握力运动对肾血管的反应：同情与自动调节控制。

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摘要

Static exercise causes activation of the sympathetic nervous system, which results in increased blood pressure (BP) and renal vascular resistance (RVR). The question arises as to whether renal vasoconstriction that occurs during static exercise is due to sympathetic activation and/or related to a pressure-dependent renal autoregulatory mechanism. To address this issue, we monitored renal blood flow velocity (RBV) responses to two different handgrip (HG) exercise paradigms in 7 kidney transplant recipients (RTX) and 11 age-matched healthy control subjects. Transplanted kidneys are functionally denervated. Beat-by-beat analyses of changes in RBV (observed via duplex ultrasound), BP, and heart rate were performed during HG exercise in all subjects. An index of RVR was calculated as BP/RBV. In protocol 1, fatiguing HG exercise (40% of maximum voluntary contraction) led to significant increases in RVR in both groups. However, at the end of exercise, RVR was more than fourfold higher in control subjects thanin the RTX group (88 vs. 20% increase over baseline; interaction, P < 0.001). In protocol 2, short bouts of HG exercise (15 s) led to significant increases in RVR at higher workloads (50 and 70% of maximum voluntary contraction) in the control subjects (P < 0.001). RVR did not increase in the RTX group. In conclusion, we observed grossly attenuated renal vasoconstrictor responses to exercise in RTX subjects, in whom transplanted kidneys were considered functionally denervated. Our results suggest that renal vasoconstrictor responses to exercise in conscious humans are mainly dependent on activation of a neural mechanism.
机译：静态运动会导致交感神经系统激活，从而导致血压（BP）和肾血管阻力（RVR）升高。在静态运动过程中发生的肾血管收缩是否是由于交感神经激活引起的和/或与压力依赖的肾脏自身调节机制有关而引起的问题。为了解决这个问题，我们在7位肾脏移植接受者（RTX）和11位年龄匹配的健康对照受试者中监测了对两种不同手柄（HG）运动范例的肾血流速度（RBV）反应。移植的肾功能失神经。在所有受试者的HG运动期间，对RBV（通过双工超声观察），血压和心率的变化进行逐次分析。 RVR的指数计算为BP / RBV。在方案1中，令人疲劳的HG运动（最大自愿收缩的40％）导致两组的RVR显着增加。然而，在运动结束时，对照组的RVR比RTX组高出四倍（比基线增加88％vs. 20％;相互作用，P <0.001）。在方案2中，在对照组中，短时间的HG运动（15 s）导致较高工作量（最大自愿收缩的50％和70％）下的RVR显着增加（P <0.001）。 RTX组中RVR没有增加。总之，我们在RTX受试者中观察到运动后肾血管收缩剂的反应显着减弱，在这些受试者中，移植肾被认为是功能失神经的。我们的结果表明，有意识的人类对运动的肾脏血管收缩反应主要取决于神经机制的激活。

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