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首页> 外文期刊>American Journal of Physiology >Moderate maternal vitamin A deficiency alters myogenic regulatory protein expression and perinatal organ growth in the rat.
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Moderate maternal vitamin A deficiency alters myogenic regulatory protein expression and perinatal organ growth in the rat.

机译：母体中度维生素A缺乏症会改变大鼠的肌源性调节蛋白表达和围产期器官生长。

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摘要

Vitamin A deficiency is one of the most common dietary deficiencies in the developing world and is a major health concern where it is associated with increased risk of fetal and infant mortality and morbidity. Early studies in the rat demonstrated that, in addition to respiratory problems, neonates showed evidence of mobility problems in response to moderate vitamin A deficiency. This study investigated whether moderate deficiency of this vitamin plays a role in regulating key skeletal muscle regulatory pathways during development. Thirty female rats were fed vitamin A-moderate (VAM) or vitamin A-sufficient diets from weaning and throughout pregnancy. Fetal and neonatal hindlimb and muscle samples were collected on days 13.5, 15.5, 17.5, and 19.5 of pregnancy and 1 day following birth. Mothers fed the VAM diet had reduced retinol concentrations at all time points studied (P < 0.01), and neonates had reduced relative lung weights (P < 0.01). Fetal weight and survival did not differ between groups but neonatal survival was lower in the VAM group where neonates had increased relative heart weights (P < 0.05). Analysis of myogenic regulatory factor expression and calcineurin signaling in fetuses and neonates demonstrated decreased protein levels of myf5 [50% at 17.5 dg (P < 0.05)], myogenin [70% at birth (P < 0.001)], and myosin heavy chain fast [50% at birth (P < 0.05)] in response to moderate vitamin A deficiency. Overall, these changes suggest that vitamin A status during pregnancy may have important implications for fetal muscle development and subsequent muscle function in the offspring.
机译：维生素A缺乏症是发展中国家最常见的饮食缺乏症之一，也是主要的健康问题，它与胎儿和婴儿死亡和发病的风险增加有关。在大鼠中的早期研究表明，除呼吸系统问题外，新生儿还显示出对中度维生素A缺乏症有反应的行动不便的证据。这项研究调查了这种维生素的中度缺乏在发育过程中是否在调节关键的骨骼肌调节途径中起作用。从断奶到整个怀孕期间，对30只雌性大鼠饲喂中度维生素A（VAM）或维生素A足够的饮食。在怀孕的第13.5、15.5、17.5和19.5天以及出生后1天收集胎儿和新生儿的后肢和肌肉样本。接受VAM饮食喂养的母亲在所有研究的时间点均降低了视黄醇浓度（P <0.01），而新生儿的相对肺重量也有所降低（P <0.01）。两组之间的胎儿体重和存活率无差异，但在VAM组中新生儿的存活率较低，其中新生儿的相对心脏重量增加（P <0.05）。胎儿和新生儿的肌源性调节因子表达和钙调神经磷酸酶信号分析表明，myf5的蛋白水平降低了[17.5 dg时为50％（P <0.05）]，肌生成素[出生时为70％（P <0.001）]和肌球蛋白重链快[出生时50％（P <0.05）]对中度维生素A缺乏症的反应。总体而言，这些变化表明，怀孕期间维生素A的状况可能对胎儿的肌肉发育以及后代的后续肌肉功能产生重要影响。

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