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首页> 外文期刊>American Journal of Physiology >Luminal glucose sensing in the rat intestine has characteristics of a sodium-glucose cotransporter.
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Luminal glucose sensing in the rat intestine has characteristics of a sodium-glucose cotransporter.

机译：大鼠肠道中的葡萄糖葡萄糖感测具有钠-葡萄糖共转运蛋白的特征。

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摘要

The presence of glucose in the intestinal lumen elicits a number of changes in gastrointestinal function, including inhibition of gastric emptying and food intake and stimulation of pancreatic and intestinal secretion. The present study tested the hypothesis that Na(+)-glucose cotransporter (SGLT)-3, a member of the SGLT family of transport proteins, is involved in detection of luminal glucose in the intestine. Gastric emptying, measured in awake rats, was significantly inhibited by perfusion of the intestine with glucose (60 and 90 mg); this effect was mimicked by alpha-methyl glucose (nonmetabolizable substrate of SGLT-1 and -3) but not 2-deoxy-d-glucose (substrate for GLUT-2) or isoosmotic mannitol. Gastric motility and intestinal fluid secretion, measured in anesthetised rats, were significantly inhibited and stimulated, respectively, by duodenal glucose but not galactose, which has a much lower affinity for SGLT-3 than glucose. Duodenal glucose but not galactose stimulated the release of 5-HT intomesenteric lymph and stimulated the discharge of duodenal vagal afferent fibers. mRNA for SGLT-3 was identified in the duodenal mucosa. Together these data suggest that detection of glucose in the intestine may involve SGLT-3, possibly expressed by enterochromaffin cells in the intestinal mucosa, and release of 5-HT.
机译：肠腔中葡萄糖的存在会引起胃肠功能的许多变化，包括抑制胃排空和食物摄入以及刺激胰腺和肠道分泌。本研究检验了以下假设：Na（+）-葡萄糖共转运蛋白（SGLT）-3是SGLT转运蛋白家族的成员，参与肠道内葡萄糖的检测。在清醒大鼠中测得的胃排空被肠内葡萄糖（60和90 mg）灌注显着抑制。这种作用可以通过α-甲基葡萄糖（SGLT-1和-3的不可代谢底物）来模仿，但不能通过2-deoxy-d-葡萄糖（GLUT-2的底物）或等渗甘露醇来模仿。十二指肠葡萄糖显着抑制和刺激了麻醉大鼠中的胃动力和肠液分泌，但半乳糖却没有，因为半乳糖对SGLT-3的亲和力比葡萄糖低得多。十二指肠葡萄糖而不是半乳糖刺激了5-HT进入肠系膜淋巴的释放，并刺激了十二指肠迷走神经传入纤维的排出。在十二指肠粘膜中鉴定了SGLT-3的mRNA。这些数据加在一起表明，肠中葡萄糖的检测可能涉及SGLT-3（可能由肠粘膜中的肠嗜铬细胞表达）和5-HT的释放。

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