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首页> 外文期刊>American Journal of Physiology >Combination unilateral amygdaloid and ventromedial hypothalamic lesions: evidence for a feeding pathway.
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Combination unilateral amygdaloid and ventromedial hypothalamic lesions: evidence for a feeding pathway.

机译：单侧杏仁核和下丘脑腹膜病变的联合：喂养途径的证据。

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Previous studies have reported hyperphagia and obesity in female rats with bilateral lesions of the most posterodorsal part of the amygdala. In rats with unilateral posterodorsal amygdaloid lesions, a dense pattern of anterograde degeneration appears in the ipsilateral ventromedial hypothalamus, but not the contralateral nucleus. In the present study, female rats with unilateral ventromedial hypothalamic lesions or sham lesions were given either sham lesions or unilateral lesions of the posterodorsal amygdala (PDA) 20 days later. Unilateral lesions of the ventromedial hypothalamus resulted in hyperphagia and excessive weight gain. Subsequent amygdaloid lesions that were contralateral to the initial hypothalamic lesions resulted in hyperphagia and additional excessive weight gains, but amygdaloid lesions ipsilateral to the initial hypothalamic lesions did not. It is concluded that the effects of the two lesions on body weight are not additive and that the PDA and ventromedial hypothalamus are part of the same ipsilateral pathway regulating feeding behavior and body weight regulation.
机译：先前的研究报道了雌性大鼠的杏仁核最后嗅部位双侧病变的食欲亢进和肥胖。在具有单侧后背杏仁核病变的大鼠中，同侧腹膜下丘脑中出现密集的顺行性变性模式，但对侧核中则没有。在本研究中，对具有单侧腹膜下丘脑损伤或假性损伤的雌性大鼠在20天后给予假体损伤或后背杏仁核（PDA）的单侧损伤。腹侧下丘脑的单侧病变导致食欲亢进和体重增加过多。随后与最初的下丘脑病变对侧的杏仁状病变导致吞噬和额外的体重增加，但是与最初的下丘脑病变同侧的杏仁状病变则没有。结论是，这两个病变对体重的影响不是累加的，并且PDA和腹膜下丘脑是同一同侧途径中调节进食行为和体重的一部分。

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