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首页> 外文期刊>American Journal of Physiology >Possible neural mediation of the central effects of oxytocin on uterine motility.
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Possible neural mediation of the central effects of oxytocin on uterine motility.

机译：催产素对子宫运动的中心作用的可能神经调节。

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The central nervous system contains the nuclei at the origin of autonomic and neuroendocrine pathways to the uterus. Although the anatomical basis of these pathways is known, the conditions of their recruitment and their interactions in the context of copulation remain to be explored. We tested the hypothesis that some central mechanisms could simultaneously recruit both pathways to the uterus. In this aim, we recorded intrauterine pressure changes in anesthetized female rats at the estrus stage after intracerebroventricular (ICV) administration of oxytocin (OT). Doses of 0.3-300 ng elicited increases of frequency and amplitude of uterine contractions. These effects were partly mimicked by the OT agonist [Thr(4),Gly(7)]OT but not by arginine vasopressin. They were blocked by the OT receptor antagonist atosiban delivered either ICV or intravenously. The latter suggests that ICV OT activated the systemic release of OT. The effects of OT were also blocked by hexamethonium, a ganglionic blocking agent, by atropine, a muscarinic receptor antagonist, and by N(omega)-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis. The results reveal that ICV OT recruits autonomic efferent pathways to the uterus. These results support our hypothesis that the activation of central nuclei can promote uterine contractility, and that OT may be a central coordinator of autonomic and neuroendocrine pathways. The hypothalamus, the source of direct OT-ergic projections to the pituitary, the brain stem, and the spinal cord, may be a target of central OT.
机译：中枢神经系统在通往子宫的自主神经通路和神经内分泌通路的起源处包含核。尽管这些途径的解剖学基础是已知的，但在交配的情况下其募集条件及其相互作用的条件仍有待探索。我们检验了一些中心机制可以同时募集两种途径进入子宫的假说。为此目的，我们记录了脑室内（ICV）施用催产素（OT）后，在发情期麻醉的雌性大鼠子宫内的压力变化。 0.3-300 ng的剂量引起子宫收缩的频率和幅度增加。这些作用在某种程度上被OT激动剂[Thr（4），Gly（7）] OT模仿，但未被精氨酸加压素模仿。它们被ICV或静脉内递送的OT受体拮抗剂阿托西班阻断。后者表明ICV OT激活了OT的全身释放。 OT的作用还被神经节阻滞剂六甲铵，毒蕈碱受体拮抗剂阿托品和一氧化氮合成抑制剂N（ω）-硝基-L-精氨酸甲酯所阻滞。结果表明，ICV OT募集了自主的子宫传出途径。这些结果支持我们的假设，即中枢核的激活可以促进子宫收缩，而OT可能是自主神经通路和神经内分泌通路的中心协调器。下丘脑是脑部OT的靶标，下丘脑是脑垂体，脑干和脊髓直接OT能量投射的来源。

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