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首页> 外文学位 >Activation of the central nucleus of the amygdala following anxiolytic and anxiogenic drugs: The neural circuits mediating expression of early growth response gene-1.
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Activation of the central nucleus of the amygdala following anxiolytic and anxiogenic drugs: The neural circuits mediating expression of early growth response gene-1.

机译：抗焦虑药和焦虑药后杏仁核中央核的激活：介导早期生长反应基因-1表达的神经回路。

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摘要

This dissertation was aimed at elucidating the role of the central nucleus of the amygdala (CeA) following administration of systemic and psychogenic stimuli. Psychogenic stimuli include those involved in fear conditioning, restraint, and foot-shock, and are transmitted to the CeA via sensory and somatosensory paths. In comparison, systemic stimuli include cardiovascular, osmotic, and immune challenges, and are transmitted to the CeA via visceral efferent pathways.; Studies measuring changes in expression of immediate-early genes (IEG) have demonstrated increases in the lateral nucleus of the amygdala, but not in the CeA, following fear conditioning. Furthermore, IEG activity decreases in the lateral but increases in the CeA when fear conditioning is blocked using anxiolytic drugs, suggesting that the CeA may be a passive participant in fear conditioning but active when fear is inhibited. However, the CeA is also part of the autonomic system involved in processing and directing visceral information and output, and the effects of anxiolytics in the CeA may be due to visceral stimulation by the drugs. Two sets of studies were conducted to investigate IEG expression in the CeA. The first study looked at IEG expression following anxiolytic and anxiogenic drugs and data revealed that both types of drugs induced IEG activity in the CeA, suggesting that IEG induction in the CeA is not specific to anxiolytic compounds. To determine if the psychogenic properties of diazepam (DZ), conveyed via the BLA complex, were responsible for activation of the CeA, lesions of the BLA complex were performed. In addition, lesions of the nucleus tractus solitarius (NTS) were performed to determine if activation of the CeA was due to visceral stimulation by DZ. These studies revealed that BLA lesions did not reduce diazepam induction of IEG in the CeA, but lesions of the NTS blocked DZ induction in the CeA. These studies clarify the role of the CeA in psychogenic vs. systemic information processing, and suggest an additional role for the CeA in addition to its role during fear conditioning. This data suggests a prominent role of the CeA in processing visceral sensory efferent information and in the maintenance of physiological homeostasis.
机译：本论文旨在阐明全身和心理刺激后杏仁核（CeA）中央核的作用。心因性刺激包括与恐惧调节，克制和足部冲击有关的刺激，并通过感觉和体感途径传递给CeA。相比之下，全身性刺激包括心血管，渗透和免疫刺激，并通过内脏传出途径传递给CeA。评估恐惧症状后，测量立即早期基因（IEG）表达变化的研究表明杏仁核的外侧核增加，而CeA则没有。此外，当使用抗焦虑药阻止恐惧调节时，IEG的外侧活动减少，但CeA升高，这表明CeA可能是恐惧调节的被动参与者，而在恐惧被抑制时则活跃。然而，CeA也是参与处理和指导内脏信息和输出的自主系统的一部分，CeA中抗焦虑药的作用可能是由于药物对内脏的刺激。进行了两组研究来研究IEG在CeA中的表达。第一项研究着眼于抗焦虑药和抗焦虑药后的IEG表达，数据显示这两种药物均可诱导CeA中的IEG活性，这表明CeA中的IEG诱导并非对抗焦虑化合物具有特异性。为了确定通过BLA复合物传递的地西epa（DZ）的心理特性是否与CeA的激活有关，对BLA复合物进行了损伤。另外，对孤束核（NTS）进行损伤以确定CeA的激活是否是由于DZ的内脏刺激引起的。这些研究表明，BLA病变并未减少CeA中地西epa的IEG诱导，但NTS病变阻止了CeA中的DZ诱导。这些研究阐明了CeA在心理性和系统性信息处理中的作用，并暗示了CeA除了在恐惧调节中的作用外，还具有其他作用。该数据表明，CeA在处理内脏感觉传出信息和维持生理稳态方面起着重要作用。

著录项

  • 作者

    Thompson, Barbara L.;

  • 作者单位

    University of Delaware.;

  • 授予单位 University of Delaware.;
  • 学科 Psychology Psychobiology.; Biology Neuroscience.; Health Sciences Pharmacology.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 116 p.
  • 总页数 116
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 心理学;神经科学;药理学;
  • 关键词

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