• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Acute, same-day effects of antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes mellitus.
【24h】

Acute, same-day effects of antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes mellitus.

机译：前期运动对1型糖尿病对随后低血糖的反调节反应的急性，即日影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Exercise-induced hypoglycemia can occur within hours after exercise in type 1 diabetes mellitus (T1DM) patients. This study tested the hypothesis that an acute exercise bout causes (within hours) blunted autonomic and metabolic responses to subsequent hypoglycemia in patients with T1DM. Twelve T1DM patients (3 W/9 M) were studied during a single-step, 2-h hyperinsulinemic (572 +/- 4 pmol/l) hypoglycemic (2.8 +/- 0.1 mmol/l) clamp 2 h after either a hyperinsulinemic euglycemic (AM EUG) or hypoglycemic clamp (AM HYPO) or after sitting in a chair with basal insulin infusion (AM CON) or 90 min of moderate-intensity exercise (50% Vo(2 max), AM EX). Both AM HYPO and AM EX significantly blunted epinephrine responses and muscle sympathetic nerve activity responses to subsequent hypoglycemia compared with both control groups. Endogenous glucose production was significantly lower and the exogenous glucose infusion rate needed to maintain the hypoglycemic level was significantly greater during subsequent hypoglycemia in AM EX vs. CON. Rate of glucose disposal (Rd) was significantly reduced following AM HYPO. In summary, within 2.5 h, both moderate-intensity AM EX and AM HYPO blunted key autonomic counterregulatory responses. Despite this, glucose Rd was reduced during afternoon hypoglycemia following morning hypoglycemia, indicating posthypoglycemic insulin resistance. After morning exercise, endogenous glucose production was blunted, but glucose Rd was maintained during afternoon hypoglycemia, thereby indicating reduced metabolic defenses against hypoglycemia. These data suggest that exercise-induced counterregulatory failure can occur very rapidly, increasing the risk for hypoglycemia in T1DM within hours.
机译：1型糖尿病（T1DM）患者在运动后数小时内会发生运动诱发的低血糖。这项研究检验了以下假设：急性运动发作会在几小时内导致T1DM患者对随后的低血糖的自主神经和代谢反应减弱。在12次T1DM患者中（3 W / 9 M）在每次2小时高血糖（2.8 +/- 0.1 mmol / l）降血糖（2.8 +/- 0.1 mmol / l）的单步，2小时高血糖治疗期间进行了研究正常血糖（AM EUG）或降血糖钳（AM HYPO）或坐在椅子上进行基础胰岛素输注（AM CON）或90分钟中等强度运动（50％Vo（2 max），AM EX）。与两个对照组相比，AM HYPO和AM EX对后继低血糖的肾上腺素反应和肌肉交感神经活性反应均明显减弱。在随后的AM EX低血糖患者中，与CON相比，内源性葡萄糖生成量显着降低，维持低血糖水平所需的外源性葡萄糖输注速率显着提高。 AM HYPO后，葡萄糖处置率（Rd）显着降低。总之，在2.5小时内，中等强度的AM EX和AM HYPO均减弱了关键的自主神经反调节反应。尽管如此，在早晨低血糖后的下午低血糖期间，葡萄糖Rd降低，表明低血糖后胰岛素抵抗。早晨运动后，内源性葡萄糖生成减弱，但下午低血糖期间葡萄糖Rd保持不变，从而表明针对低血糖的代谢防御能力降低。这些数据表明，运动引起的反调节衰竭可能很快发生，从而在数小时内增加了T1DM中低血糖的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号