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The 'wisdom' of lung surfactant: balancing host defense and surface tension-reducing functions

机译:肺表面活性剂的“智慧”:平衡宿主防御和降低表面张力的功能

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摘要

the mixture of lipids and proteins that comprises pulmonary surfactant is both complex and multifunctional. Although surfactant was originally identified as a lipoprotein complex that reduces surface tension at the air-liquid interface of the lung (4, 20), both in vitro and in vivo studies support a second important role for surfactant in modulating lung host defense (reviewed in Refs. 12, 13, 23). The surfactant lipoprotein complex consists predominately of lipids and four proteins known as surfactant protein (SP) -A, -B, -C, and -D; all these components are synthesized and secreted by alveolar epithelial type II cells in response to a variety of stimuli, including a deep breath and exercise
机译:包含肺表面活性剂的脂质和蛋白质混合物既复杂又多功能。尽管表面活性剂最初被认为是一种脂蛋白复合物,可降低肺气液界面的表面张力(4、20),但体外和体内研究均支持表面活性剂在调节肺部宿主防御方面的第二重要作用(综述见参考文献12、13、23)。表面活性剂脂蛋白复合物主要由脂质和四种称为表面活性剂蛋白(SP)的蛋白-A,-B,-C和-D组成。所有这些成分都是由II型肺泡上皮细胞合成并分泌的,以响应各种刺激,包括深呼吸和运动

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