首页> 外文期刊>American Journal of Physiology >Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology.
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Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology.

机译:胃肠道中的味觉受体。二。钙敏感受体对L-氨基酸的敏感:对胃肠生理的影响。

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摘要

The extracellular calcium-sensing receptor (CaR) is a multimodal sensor for several key nutrients, notably Ca2+ ions and L-amino acids, and is expressed abundantly throughout the gastrointestinal tract. While its role as a Ca2+ ion sensor is well recognized, its physiological significance as an L-amino acid sensor and thus, in the gastrointestinal tract, as a sensor of protein ingestion is only now coming to light. This review focuses on the CaR's amino acid sensing properties at both the molecular and cellular levels and considers new and putative physiological roles for the CaR in the amino acid-dependent regulation of gut hormone secretion, epithelial transport, and satiety.
机译:细胞外钙敏感受体(CaR)是多种关键营养素(尤其是Ca2 +离子和L-氨基酸)的多模式传感器,在胃肠道中大量表达。尽管人们公认其作为Ca2 +离子传感器的作用,但其作为L-氨基酸传感器的生理意义以及因此在胃肠道中作为蛋白质摄入的传感器的重要性才刚刚被人们所认识。这篇综述集中在分子水平和细胞水平上CaR的氨基酸感测特性,并考虑了CaR在肠道激素分泌,上皮运输和饱腹感的氨基酸依赖性调节中的新的和假定的生理作用。

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