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首页> 外文期刊>American Journal of Physiology >Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty.
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Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty.

机译：甘丙肽样肽对大鼠黄体生成激素分泌的影响：性二态性反应和雄性青春期敏感性增强。

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摘要

Reproductive function is exquisitely sensitive to adequacy of nutrition and fuel reserves, through mechanisms that are yet to be completely elucidated. Galanin-like peptide (GALP) has recently emerged as another neuropeptide link that couples reproduction and metabolism. However, although the effects of GALP on luteinizing hormone (LH) secretion have been studied, no systematic investigation on how these responses might differ along sexual maturation and between sexes has been reported. Moreover, the influence of metabolic status and potential interplay with other relevant neurotransmitters controlling LH secretion remain ill defined. These facets of GALP physiology were addressed herein. Intracerebral injection of GALP to male rats induced a dose-dependent increase in serum LH levels, the magnitude of which was significantly greater in pubertal than in adult males. In contrast, negligible LH responses to GALP were detected in pubertal or adult female rats at diestrus. Neonatal androgen treatment to females failed to "masculinize" the pattern of LH response to GALP. In addition, metabolic stress by short-term fasting did not prevent but rather amplified LH responses to GALP in pubertal males, whereas these responses were abrogated by pharmacological inhibition of nitric oxide synthesis. We conclude that the ability of GALP to evoke LH secretion is sexually differentiated, with maximal responses at male puberty, a phenomenon which was not reverted by manipulation of sex steroid milieu during the critical neonatal period and was sensitive to metabolic stress. This state of LH hyperresponsiveness may prove relevant for the mechanisms relaying metabolic status to the reproductive axis in male puberty.
机译：通过尚未完全阐明的机制，生殖功能对营养和燃料储备的充足非常敏感。甘丙肽样肽（GALP）最近已成为另一种耦合生殖和代谢的神经肽连接。但是，尽管已经研究了GALP对促黄体生成激素（LH）分泌的影响，但是还没有关于这些反应在性成熟时以及两性之间如何发生差异的系统研究。而且，代谢状态和与控制LH分泌的其他相关神经递质的潜在相互作用的影响仍然不清楚。本文论述了GALP生理学的这些方面。给雄性大鼠脑内注射GALP会引起血清LH水平的剂量依赖性增加，青春期的这种程度明显大于成年雄性。相反，在青春期或成年雌性雌性大鼠中，对GALP的LH反应可忽略不计。对女性的新生儿雄激素治疗未能“男性化” LH对GALP的反应方式。此外，短期禁食引起的代谢应激并不能阻止而是增强了青春期男性对GALP的LH反应，而这些反应由于一氧化氮合成的药理抑制作用而被取消。我们得出的结论是，GALP引起LH分泌的能力在性别上有所区别，在男性青春期反应最大，这种现象在新生儿关键时期不能通过控制性类固醇环境恢复，并且对代谢压力敏感。 LH高反应性状态可能与男性青春期将代谢状态传递到生殖轴的机制有关。

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