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首页> 外文期刊>American Journal of Physiology >Relationship between changes in brachial artery flow-mediated dilation and basal release of nitric oxide in subjects with Type 2 diabetes.
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Relationship between changes in brachial artery flow-mediated dilation and basal release of nitric oxide in subjects with Type 2 diabetes.

机译：2型糖尿病患者肱动脉血流介导的扩张变化与一氧化氮基础释放之间的关系。

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Assessment of flow-mediated dilation (FMD) after forearm ischemia is widely used as a noninvasive bioassay of stimulated nitric oxide (NO)-mediated conduit artery vasodilator function in vivo. Whether this stimulated endothelial NO function reflects basal endothelial NO function is unknown. To test this hypothesis, retrospective analysis of randomized crossover studies was undertaken in 17 subjects with Type 2 diabetes; 9 subjects undertook an exercise training or control period, whereas the remaining 8 subjects were administered an angiotensin II receptor blocker or placebo. FMD was assessed by using wall tracking of high-resolution brachial artery ultrasound images in response to reactive hyperemia. Resistance vessel basal endothelium-dependent NO function was assessed by using intrabrachial administration of NG-monomethyl-L-arginine (L-NMMA) and plethysmographic assessment of forearm blood flow (FBF). FMD was higher after intervention compared with control/placebo (6.15+/-0.53 vs. 3.81+/-0.72%, P<0.001). There were no significant changes in the FBF responses to L-NMMA. Regression analysis between FMD and L-NMMA responses at entry to the study revealed an insignificant correlation (r=-0.10, P=0.7), and improvements in FMD with the interventions were not associated with changes in the L-NMMA responses (r=-0.04, P=0.9). We conclude that conduit artery-stimulated endothelial NO function (FMD) does not reflect basal resistance vessel endothelial NO function in subjects with Type 2 diabetes.
机译：前臂缺血后血流介导的扩张（FMD）的评估被广泛用作体内一氧化氮（NO）介导的导管动脉血管扩张功能的非侵入性生物测定。这种受刺激的内皮NO功能是否能反映基础内皮NO功能尚不清楚。为了验证这一假设，对17名2型糖尿病患者进行了随机交叉研究的回顾性分析。 9名受试者进行了运动训练或控制期，而其余8名受试者接受了血管紧张素II受体阻滞剂或安慰剂的治疗。使用反应性充血反应的高分辨率肱动脉超声图像的壁跟踪评估FMD。通过臂内注射NG-单甲基-L-精氨酸（L-NMMA）和体积描记法评估前臂血流（FBF），评估了耐药血管基底内皮依赖性NO功能。干预后的FMD高于对照组/安慰剂（6.15 +/- 0.53 vs. 3.81 +/- 0.72％，P <0.001）。 FBF对L-NMMA的反应无明显变化。进入研究前，FMD和L-NMMA反应之间的回归分析显示无显着相关性（r = -0.10，P = 0.7），干预后FMD的改善与L-NMMA反应的变化无关（r = -0.04，P = 0.9）。我们得出的结论是，在患有2型糖尿病的受试者中，导管动脉刺激的内皮一氧化氮功能（FMD）不能反映基底阻力血管内皮一氧化氮的功能。

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