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首页> 外文期刊>American Journal of Physiology >Niacin-bound chromium enhances myocardial protection from ischemia-reperfusion injury.
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Niacin-bound chromium enhances myocardial protection from ischemia-reperfusion injury.

机译：烟酸结合的铬增强了心肌对缺血-再灌注损伤的保护作用。

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摘要

A novel niacin-bound, chromium-based energy formula (EF; InterHealth Nutraceuticals, Benicia, CA) has been developed in conjunction with D-ribose, caffeine, ashwagandha extract (containing 5% withanolides), and selected amino acids. We have assessed the efficacy of oral administration of EF (40 mg x kg body wt(-1) x day(-1)) in male and female rats over a period of 90 consecutive days on the cardiovascular and pathophysiological functions in an isolated rat heart model. After 30, 60, and 90 days of treatment with EF, the hearts of male and female rats were subjected to 30 min of global ischemia followed by 2 h of reperfusion and were measured for myocardial ATP, creatine phosphate (CP), phosphorylated AMP kinase (p-AMPK), and heat shock proteins. Myocardial ATP and CP levels were increased in both male and female rats after EF treatment compared with the controls. Western blot analyses were performed to quantify the expression of stress-related proteins such as heat shock proteins (HSP-70, -32, and -25) and are found to be increased in both male and female rats after EF treatment. The p-AMPK level, which is a sensor for the energy state in various cell types, was also found to be increased after treatment with EF in both male and female rats. Aortic flow, maximum first derivative of developed pressure, left ventricular developed pressure, and infarct size were observed after ischemia-reperfusion and found to be significantly improved in EF-treated rats compared with control animals. Thus EF demonstrated long-term safety as well as exhibiting significant cardioprotective ability during ischemia and reperfusion injury by increased energy production, improved cardiac function, and reduced infarct size.
机译：结合D-核糖，咖啡因，ashwagandha提取物（含有5％的糖醇）和选定的氨基酸，开发了一种新的与烟酸结合的铬基能量公式（EF; InterHealth Nutraceuticals，加利福尼亚州贝尼西亚）。我们评估了连续90天内在雄性和雌性大鼠中口服EF（40 mg x kg体重（-1）x天（-1））对离体大鼠心血管和病理生理功能的功效心脏模型。 EF治疗30、60和90天后，对雄性和雌性大鼠的心脏进行30分钟的整体缺血，然后再灌注2 h，并测量其心肌ATP，磷酸肌酸（CP），磷酸化的AMP激酶（p-AMPK）和热激蛋白。与对照组相比，EF治疗后的雄性和雌性大鼠的心肌ATP和CP水平均升高。进行蛋白质印迹分析以量化应激相关蛋白（如热休克蛋白（HSP-70，-32和-25））的表达，发现在EF治疗后，雄性和雌性大鼠中的蛋白均增加。在雄性和雌性大鼠中，经EF治疗后，p-AMPK的水平也可以升高，这是各种细胞类型中能量状态的传感器。在缺血-再灌注后观察到主动脉血流，最大发展压力的最大一阶导数，左心室发展压力和梗死面积，与对照动物相比，EF治疗大鼠的主动脉流量，左心室发展最大压力和梗死面积明显改善。因此，EF通过提高能量产生，改善心脏功能和减小梗塞面积，表现出长期安全性，并在缺血和再灌注损伤期间表现出显着的心脏保护能力。

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