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首页> 外文期刊>American Journal of Physiology >The dorsal vagal complex as a site for cocaine- and amphetamine-regulated transcript peptide to suppress gastric emptying.
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The dorsal vagal complex as a site for cocaine- and amphetamine-regulated transcript peptide to suppress gastric emptying.

机译：背迷走神经复合体是可卡因和苯丙胺调节的转录肽抑制胃排空的部位。

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摘要

Cocaine- and amphetamine-regulated transcript-derived peptides (CARTp) and corticotropin-releasing factor (CRF) alter feeding and gastrointestinal function after central administration, and the gastric inhibitory effects are mediated through CRF. We hypothesized that dorsal hindbrain effects of CARTp on gastric emptying are mediated by the vagus nerve and that the dorsal vagal complex (DVC) is a site of action for the gastric inhibitory effects of both CARTp and CRF. Rats were equipped with chronic intragastric fistulas and guide cannulas aimed at the fourth ventricle or the DVC. Fourth intracerebroventricular CARTp-induced suppression of 12 ml glucose (12.5%) gastric emptying during fill was blocked by subdiaphragmatic vagotomy. To establish whether the DVC may be a site of action for CARTp and/or CRF, intraparenchymal microinjections (0.25 microl) of CARTp (0.1 and 0.5 microg) and CRF (5 and 10 pmol) were administered in the DVC. Each dose, previously shown to be ineffective after fourth intracerebroventricular administration, suppressed gastric emptying during gastric fill vs. vehicle, but neither peptide changed gastric secretion volume or gastric acidity. The results indicate that the DVC is a target site for CRF and CARTp to inhibit gastric emptying and that the vagus mediates dorsal hindbrain effects of CARTp on gastric motor function.
机译：可卡因和苯丙胺调节的转录物衍生肽（CARTp）和促肾上腺皮质激素释放因子（CRF）改变中央给药后的进食和胃肠功能，并且胃抑制作用通过CRF介导。我们假设迷走神经介导了CARTp对胃排空的背后脑作用，而背迷走神经复合体（DVC）是CARTp和CRF对胃抑制作用的作用部位。大鼠装备有慢性胃内瘘和导向套管，对准第四脑室或DVC。 fill下迷走神经切断术阻断了第四次脑室内CARTp诱导的12 ml葡萄糖（12.5％）胃排空抑制。为了确定DVC是否可能是CARTp和/或CRF的作用部位，在DVC中进行了CARTp（0.1和0.5微克）和CRF（5和10 pmol）的实质内微注射（0.25微升）。先前证明在第四次脑室内给药后每种剂量均无效，与媒介物相比，在胃充盈期间抑制了胃排空，但是肽均未改变胃分泌量或胃酸度。结果表明，DVC是CRF和CARTp抑制胃排空的靶位，迷走神经介导CARTp的后脑对胃运动功能的影响。

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