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首页> 外文期刊>American Journal of Physiology >Oxygen consumption and metabolite concentrations during transitions between different work intensities in heart.
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Oxygen consumption and metabolite concentrations during transitions between different work intensities in heart.

机译：心脏不同工作强度之间转换期间的耗氧量和代谢物浓度。

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摘要

Steady-state metabolite (ADP, ATP, P(i), PCr, and NADH) concentrations usually differ little between different workloads with significantly different oxygen consumption rates in the heart. However, during transitions between steady states, metabolite concentrations may in some cases change transiently, exhibiting a significant overshoot or undershoot, whereas in other cases they approach near-exponentially new steady-state values. Oxygen consumption rate usually reaches the new steady-state value very quickly (within a few seconds). The present in silico studies, performed using a previously developed computer model of oxidative phosphorylation in the heart, demonstrate that such a behavior of the oxidative phosphorylation system can be reproduced only under the assumption that ATP usage, substrate dehydrogenation, and (particular steps of) oxidative phosphorylation are directly activated to a similar extend by some cytosolic factor/mechanism during transition from low work to high work (the so-called parallel-activation mechanism). Computer simulations show that some differences observed between different experimental systems can be explained by a slightly different balance of the activation of particular components of the system and/or by a delay in time of the activation/inactivation of substrate dehydrogenation and oxidative phosphorylation during low-to-high and high-to-low work transitions. Thus the presented theoretical approach offers a general idea that is able to unify, at least semiquantitatively, different experimental data available in the literature.
机译：稳态代谢物（ADP，ATP，P（i），PCr和NADH）的浓度在不同的工作量之间通常差异不大，心脏的耗氧率也有显着差异。但是，在稳态之间的过渡期间，代谢物浓度在某些情况下可能会发生短暂变化，表现出明显的上冲或下冲，而在其他情况下，它们接近接近指数的新稳态值。耗氧率通常很快（几秒钟内）达到新的稳态值。使用先前开发的心脏中氧化磷酸化的计算机模型进行的计算机模拟研究表明，只有在使用ATP，底物脱氢和（特定步骤）的前提下，才能复制氧化磷酸化系统的这种行为。在从低功到高功的过渡过程中，氧化磷酸化被某些胞质因子/机制直接激活到类似的程度（所谓的平行激活机制）。计算机模拟表明，在不同的实验系统之间观察到的某些差异可以通过系统中特定组件的活化平衡稍有不同和/或在低温条件下底物脱氢和氧化磷酸化的活化/失活时间的延迟来解释。从高到高由低到高的转换。因此，所提出的理论方法提供了一种一般思想，该思想能够至少半定量地统一文献中可用的不同实验数据。

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