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首页> 外文期刊>American Journal of Physiology >Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans.
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Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans.

机译：使用同时进行的压力和速度测量来估计人体单个部位的动脉波速度。

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It has not been possible to measure wave speed in the human coronary artery, because the vessel is too short for the conventional two-point measurement technique used in the aorta. We present a new method derived from wave intensity analysis, which allows derivation of wave speed at a single point. We apply this method in the aorta and then use it to derive wave speed in the human coronary artery for the first time. We measured simultaneous pressure and Doppler velocity with intracoronary wires at the left main stem, left anterior descending and circumflex arteries, and aorta in 14 subjects after a normal coronary arteriogram. Then, in 10 subjects, serial measurements were made along the aorta before and after intracoronary isosorbide dinitrate. Wave speed was derived by two methods in the aorta: 1) the two-site distance/time method (foot-to-foot delay of pressure waveforms) and 2) a new single-point method using simultaneous pressure and velocity measurements. Coronary wave speed was derived by the single-point method. Wave speed derived by the two methods correlated well (r = 0.72, P < 0.05). Coronary wave speed correlated with aortic wave speed (r = 0.72, P = 0.002). After nitrate administration, coronary wave speed fell by 43%: from 16.4 m/s (95% confidence interval 12.6-20.1) to 9.3 m/s (95% confidence interval 6.5-12.0, P < 0.001). This single-point method allows determination of wave speed in the human coronary artery. Aortic wave speed is correlated to coronary wave speed. Finally, this technique detects the prompt fall in coronary artery wave speed with isosorbide dinitrate.
机译：由于人血管对于用于主动脉的常规两点测量技术而言太短，因此无法测量人冠状动脉的波速。我们提出了一种从波强度分析中得出的新方法，该方法可以推导单点处的波速。我们在主动脉中应用此方法，然后首次使用它来推导人冠状动脉中的波速。我们在正常冠状动脉造影后的14位受试者中测量了左主干，左前降支和回旋支以及主动脉的冠状动脉内导线的同时压力和多普勒速度。然后，在10名受试者中，在冠状动脉内异山梨醇二硝酸盐之前和之后，沿着主动脉进行了一系列测量。波速是通过主动脉中的两种方法得出的：1）两点距离/时间方法（压力波形的脚到脚延迟）和2）使用压力和速度同时测量的新单点方法。冠脉速度是通过单点法得出的。两种方法得出的波速具有很好的相关性（r = 0.72，P <0.05）。冠脉速度与主动脉速度相关（r = 0.72，P = 0.002）。施用硝酸盐后，冠状动脉速度下降了43％：从16.4 m / s（95％置信区间12.6-20.1）降至9.3 m / s（95％置信区间6.5-12.0，P <0.001）。这种单点方法可以确定人冠状动脉中的波速。主动脉速度与冠状动脉速度相关。最终，该技术检测到硝酸异山梨酯可迅速降低冠状动脉的波速。

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