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首页> 外文期刊>American Journal of Physiology >Parallel and divergent adaptations of rat soleus and plantaris to chronic exercise and hypergravity.
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Parallel and divergent adaptations of rat soleus and plantaris to chronic exercise and hypergravity.

机译：大鼠比目鱼和plant肌对慢性运动和超重力的平行和发散适应。

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摘要

It has been demonstrated that endurance exercise and chronic acceleration, i.e., hypergravity, produce comparable adaptations in a variety of physiological systems, including decreased adiposity, increased energy metabolism, and altered intermediary metabolism. Similar adaptations have not been demonstrated for skeletal muscle per se. To further differentiate between these general responses with respect to gravity and exercise, this study tested the hypothesis that chronic exercise (voluntary wheel running) and chronic acceleration (2 G via centrifugation) will induce similar changes in muscle myosin heavy chain (MHC) isoform expression in rat plantaris, a fast extensor, and in rat soleus, a slow "antigravity" extensor. The experimental design involved four groups of mature male rats (n = 8/group): 1 G and 2 G with running wheels, and 1 G and 2 G controls without running wheels. The primary observations from the study were as follows: 1) 8 wk of 2 G are an adequate stimulus for MHC compositional changes in rat plantaris and soleus muscle; 2) both exercise and +G caused an increase in the slow MHC1 isoform in soleus muscle, suggesting that loading is a primary stimulus for this shift; and 3) 2 G and exercise appeared to have differential effects on the plantaris muscle MHC isoforms, with 2 G causing an increase in MHC2b, and exercise causing a decrease in MHC2b with a concomitant increase in MHC1, suggesting that factors other than enhanced loading, possibly locomotor activity levels, are the primary stimulus for this shift.
机译：已经证明，耐力运动和慢性加速即超重力在各种生理系统中产生可比较的适应性，包括减少肥胖，增加能量代谢和改变中间代谢。对于骨骼肌本身，尚未证明类似的适应方法。为了进一步区分这些关于重力和运动的一般反应，本研究检验了以下假设，即长期运动（自愿性轮转）和慢性加速（通过离心作用产生2 G）将诱导肌肉肌球蛋白重链（MHC）亚型的相似变化在大鼠足底是快速的伸肌，而在比目鱼肌中是缓慢的“反重力”伸肌。实验设计包括四组成年雄性大鼠（n = 8 /组）：带行走轮的1 G和2 G，以及不带行走轮的1 G和2 G对照。该研究的主要观察结果如下：1）8周2 g足以刺激大鼠足底和比目鱼肌中MHC成分的变化; 2）运动和+ G都会导致比目鱼肌中MHC1慢异构体的增加，这表明负荷是这种转变的主要刺激;和3）2 G和运动似乎对plant肌MHC亚型有不同的影响，其中2 G导致MHC2b升高，运动导致MHC2b降低，同时MHC1升高，提示除了增加负荷外，可能是运动活动水平是此转变的主要刺激因素。

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