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首页> 外文期刊>American Journal of Physiology >Independent ingestion and microstructure of feeding patterns in infant rats lacking CCK-1 receptors.
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Independent ingestion and microstructure of feeding patterns in infant rats lacking CCK-1 receptors.

机译：缺乏CCK-1受体的幼鼠的独立摄入和喂养方式的微观结构。

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摘要

Otsuka Long-Evans Tokushima fatty (OLETF) rats are a strain of Long-Evans Tokushima Otsuka (LETO) rats that do not express CCK-1 receptors, developing in adulthood, hyperphagia, obesity, and non-insulin-dependent diabetes mellitus (NIDDM). We examined weight gain and meal patterns during a 30-min independent ingestion test on postnatal days 2-4 and again on days 9-11 in OLETF and LETO rat pups. OLETF pups were significantly heavier compared with their LETO controls at both ages, and they consumed significantly more of the sweet milk diet. The difference in intake can be attributed to a significant increase in meal size and duration. Number of clusters and bursts of licking within a meal were greater in OLETF rat pups, with no difference between strains in burst and cluster size. Interlick interval (ILI) was not significantly different between OLETF and LETO pups. This measure decreased on days 9-11 compared with days 2-4 in both strains. Latency to start feeding was significantly shorter on days 2-4 inOLETF vs. LETO pups, but this difference disappeared at the second test at the older age. Two- to four-day-old OLETF pups consumed a larger volume of milk during the first minute of feeding, and their initial lick rate and decay of lick rate were significantly larger compared with their LETO controls. Lack of CCK-1 receptors, or other OLETF-related abnormalities, therefore, resulted in a satiation deficit, leading to increased meal size, hyperphagia, and increased weight gain as early as 2-4 postnatal days.
机译：大冢长岛德岛肥胖（OLETF）大鼠是不表达CCK-1受体的长岛德岛大冢（LETO）大鼠，在成年期，吞噬，肥胖和非胰岛素依赖型糖尿病（NIDDM）中发展）。我们在出生后2-4天的第30天独立摄取测试中检查了体重增加和进食模式，并在OLETF和LETO大鼠幼仔中的第9-11天再次进行了检查。与两个年龄段的LETO对照组相比，OLETF幼崽均明显较重，并且它们消耗的甜牛奶饮食明显更多。摄入量的差异可归因于进餐量和进餐时间的显着增加。在OLETF大鼠幼崽中，一顿饭中团簇的数量和舔burst的次数更多，而菌株和团簇大小的菌株之间没有差异。 OLETF和LETO幼犬之间的Interlick间隔（ILI）没有显着差异。与两种菌株的2-4天相比，该措施在9-11天均下降。与LETO幼崽相比，inOLETF第2-4天开始喂食的延迟显着缩短，但是在第二次测试中，这种差异在较大的年龄就消失了。两到四天大的OLETF幼崽在喂养的第一分钟内消耗了大量的牛奶，与LETO对照相比，它们的初始舔食率和舔食率衰减明显更大。因此，缺乏CCK-1受体或其他与OLETF相关的异常会导致饱足感不足，从而导致进餐后2-4天增加进餐量，食欲亢进和体重增加。

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