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首页> 外文期刊>American Journal of Physiology >Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study.
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Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study.

机译：抑制内源性睾丸激素的产生会减弱对力量训练的反应：一项随机，安慰剂对照和盲法干预研究。

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We hypothesized that suppression of endogenous testosterone would inhibit the adaptations to strength training in otherwise healthy men. Twenty-two young men with minor experience with strength training participated in this randomized, placebo-controlled, double-blinded intervention study. The subjects were randomized to treatment with the GnRH analog goserelin (3.6 mg) or placebo (saline) subcutaneously every 4 wk for 12 wk. The strength training period of 8 wk, starting at week 4, included exercises for all major muscles [3-4 sets per exercise x 6-10 repetitions with corresponding 6- to 10-repetition maximum (RM) loads, 3/wk]. A strength test, blood sampling, and whole body DEXA scan were performed at weeks 4 and 12. Endogenous testosterone decreased significantly (P < 0.01) in the goserelin group from 22.6 +/- 5.5 (mean +/- SD) nmol/l to 2.0 +/- 0.5 (week 4) and 1.1 +/- 0.6 nmol/l (week 12), whereas it remained constant in the placebo group. The goserelin group showed no changes in isometric knee extension strength after training, whereas the placebo group increased from 240.2 +/- 41.3 to 264.1 +/- 35.3 Nm (P < 0.05 within and P = 0.05 between groups). Lean mass of the legs increased 0.37 +/- 0.13 and 0.57 +/- 0.30 kg in the goserelin and placebo groups, respectively (P < 0.05 within and P = 0.05 between groups). Body fat mass increased 1.4 +/- 1.0 kg and decreased 0.6 +/- 1.2 kg in the goserelin and placebo groups, respectively (P < 0.05 within and between groups). We conclude that endogenous testosterone is of paramount importance to the adaptation to strength training.
机译：我们假设抑制内源性睾丸激素会抑制原本健康的男性对力量训练的适应。 22名在力量训练方面经验较少的年轻人参加了这项随机，安慰剂对照，双盲干预研究。每4周将受试者随机皮下注射GnRH类似物戈舍瑞林（3.6 mg）或安慰剂（盐水），持续12 wk。从第4周开始的8 wk的力量训练期包括所有主要肌肉的运动[每运动3-4套x 6-10次重复，相应的最大（RM）负荷6至10次重复，3 / wk]。在第4周和第12周进行了强度测试，血液采样和全身DEXA扫描。戈舍瑞林组内源性睾丸激素从22.6 +/- 5.5（平均+/- SD）nmol / l显着降低（P <0.01）。 2.0 +/- 0.5（第4周）和1.1 +/- 0.6 nmol / l（第12周），而安慰剂组保持不变。戈舍瑞林组训练后未显示等距膝盖伸展力量的变化，而安慰剂组从240.2 +/- 41.3 Nm增加到264.1 +/- 35.3 Nm（组内P <0.05，组间P = 0.05）。戈舍瑞林组和安慰剂组的腿部瘦质量分别增加了0.37 +/- 0.13和0.57 +/- 0.30 kg（组内P <0.05，组间P = 0.05）。戈舍瑞林组和安慰剂组的体脂质量分别增加1.4 +/- 1.0千克和降低0.6 +/- 1.2千克（组内和组间P <0.05）。我们得出结论，内源性睾丸激素对于适应力量训练至关重要。

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