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首页> 外文期刊>American Journal of Physiology >GABA-mediated neurotransmission in the nucleus of the solitary tract alters resting ventilation following exposure to chronic hypoxia in conscious rats.
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GABA-mediated neurotransmission in the nucleus of the solitary tract alters resting ventilation following exposure to chronic hypoxia in conscious rats.

机译：GABA介导的孤立道核内神经传递改变了清醒大鼠慢性缺氧后的静息通气。

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This study investigated whether changes in GABA-mediated neurotransmission within the nucleus of the solitary tract (NTS) contribute to the changes in breathing (resting ventilation and the acute HVR) that occur following exposure to chronic hypoxia (CH). Rats were exposed to 9 days of hypobaric hypoxia (0.5 atm) and then subjected to acute hypoxic breathing trials before and after bilateral microinjections of GABA, bicuculline (a GABAA-receptor antagonist), or bicuculline plus CGP-35348 (a GABAB receptor antagonist) into the caudal regions of the NTS. Breathing was measured using whole body plethysmography. CH caused an increase in resting ventilation when the animals were breathing 30% O2 but did not alter ventilation during acute hypoxia (10% O2). GABA alone had no effect on breathing in either the control or chronically hypoxic rats. Bicuculline and bicuculline/CGP had no effect on breathing in control rats. Following CH, bicuculline and bicuculline/CGP reduced minute ventilation (VI) during acute exposure to 30% O2 but had no effect during acute exposure to 10% O2. The bicuculline-induced reduction in VI resulted from a decrease in breathing frequency (fR) and tidal volume (VT). The bicuculline/CGP-induced reduction in VI was due to a decrease in fR with no change in VT. The results suggest that changes in GABA receptor-mediated neurotransmission, within the NTS, are involved in the increase in resting ventilation that occurs following CH.
机译：这项研究调查了GABA介导的孤立神经道（NTS）核内神经传递的变化是否有助于暴露于慢性低氧（CH）后呼吸的变化（休息通气和急性HVR）。大鼠在低压低压缺氧（0.5 atm）的情况下暴露9天，然后在双侧显微注射GABA，双小分子（一种GABAA受体拮抗剂）或双小分子加CGP-35348（一种GABAB受体拮抗剂）前后进行急性低氧呼吸试验。进入NTS的尾区。使用全身体积描记法测量呼吸。当动物呼吸30％的O2时，CH导致静息通气增加，但在急性缺氧（10％的O2）期间，通气并没有改变。单独的GABA对对照组或慢性低氧大鼠的呼吸没有影响。 Bicuculline和bicuculline / CGP对对照大鼠的呼吸没有影响。继CH后，双cucuculline和bicuculline / CGP在急性暴露于30％O2时减少了分钟通气量（VI），但在急性暴露于10％O2时没有作用。双小溪诱导的VI降低是由于呼吸频率（fR）和潮气量（VT）降低。双小分子/ CGP诱导的VI降低是由于fR降低而VT无变化。结果表明，NTS中GABA受体介导的神经传递的变化与CH发生后休息通气的增加有关。

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