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首页> 外文期刊>American Journal of Physiology >Lateral ventricular ghrelin and fourth ventricular ghrelin induce similar increases in food intake and patterns of hypothalamic gene expression.
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Lateral ventricular ghrelin and fourth ventricular ghrelin induce similar increases in food intake and patterns of hypothalamic gene expression.

机译：侧脑室ghrelin和第四脑室ghrelin引起食物摄入和下丘脑基因表达模式的类似增加。

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摘要

The gut peptide ghrelin has been shown to stimulate food intake after both peripheral and central administration, and the hypothalamic arcuate nucleus has been proposed to be the major site for mediating this feeding stimulatory action. Ghrelin receptors are widely distributed in the brain, and hindbrain ghrelin administration has been shown to potently stimulate feeding, suggesting that there may be other sites for ghrelin action. In the present study, we have further assessed potential sites for ghrelin action by comparing the ability of lateral and fourth ventricular ghrelin administration to stimulate food intake and alter patterns of hypothalamic gene expression. Ghrelin (0.32, 1, or 3.2 nmol) in the lateral or fourth ventricle significantly increased food intake in the first 4 h after injection, with no ventricle-dependent differences in degree or time course of hyperphagia. One nanomole of ghrelin into either the lateral or fourth ventricle resulted in similar increases in arcuate nucleus neuropeptide Y mRNA expression. Expression levels of agouti-related peptide or proopiomelanocortin mRNA were not affected by ghrelin administration. These data demonstrate that ghrelin can affect food intake and hypothalamic gene expression through interactions at multiple brain sites.
机译：肠肽生长激素释放肽已显示出在外周和中枢给药后都能刺激食物摄取，并且下丘脑弓形核被认为是介导这种进食刺激作用的主要部位。 Ghrelin受体广泛分布于大脑中，已证明后脑Ghrelin的使用可以有效刺激进食，这表明Ghrelin的作用可能还有其他部位。在本研究中，我们通过比较侧脑室和第四脑室生长激素释放肽刺激食物摄入和改变下丘脑基因表达模式的能力，进一步评估了生长激素释放肽作用的潜在部位。注射后前4 h，外侧或第四脑室中的Ghrelin（0.32、1或3.2 nmol）显着增加了食物摄入，而吞咽困难的程度或时间进程无脑室依赖性差异。进入侧脑室或第四脑室的一纳摩尔生长素释放肽导致弓形核神经肽Y mRNA表达类似增加。 ghrelin的施用不影响刺豚鼠相关肽或proopiomelanocortin mRNA的表达水平。这些数据表明，生长素释放肽可以通过在多个大脑部位的相互作用来影响食物摄入和下丘脑基因表达。

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