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首页> 外文期刊>American Journal of Physiology >Lifetimes of epicardial rotors in panoramic optical maps of fibrillating swine ventricles.
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Lifetimes of epicardial rotors in panoramic optical maps of fibrillating swine ventricles.

机译：心房颤动的猪心室全景光学图中心外膜转子的寿命。

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摘要

During ventricular fibrillation (VF), electrical activation waves are fragmented, and the heart cannot contract in synchrony. It has been proposed that VF waves emanate from stable periodic sources (often called "mother rotors"). The objective of the present study was to determine if stable rotors are consistently present on the epicardial surface of hearts comparable in size to human hearts. Using new optical mapping technology, we imaged VF from nearly the entire ventricular surface of six isolated swine hearts. Using newly developed pattern analysis algorithms, we identified and tracked VF wave fronts and phase singularities (PS; the pivot point of a reentrant wave front). We introduce the notion of a compound rotor in which the rotor's central PS can change and describe an algorithm for automatically identifying such patterns. This prevents rotor lifetimes from being inappropriately abbreviated by wave front fragmentation and collision events near the PS. We found that stable epicardial rotors werenot consistently present during VF: only 1 of 17 VF episodes contained a compound rotor that lasted for the entire mapped interval of 4 s. However, shorter-lived rotors were common; 12.2 (SD 3.3) compound rotors with lifetime >200 ms were visible on the epicardium at any given instant. We conclude that epicardial mother rotors do not drive VF in this experimental model; if mother rotors do exist, they are intramural or septal. This paucity of persistent rotors suggests that individual rotors will eventually terminate by themselves and therefore that the continual formation of new rotors is critical for VF maintenance.
机译：在心室纤颤（VF）期间，电激活波会破碎，并且心脏无法同步收缩。已经提出，VF波从稳定的周期性源（通常称为“母转子”）发出。本研究的目的是确定在心外膜表面上是否始终存在稳定的转子，其大小可与人的心脏相媲美。使用新的光学测绘技术，我们从六个孤立的猪心脏的几乎整个心室表面成像了VF。使用新开发的模式分析算法，我们识别并跟踪了VF波前和相位奇点（PS;折返波前的枢轴点）。我们介绍了复合转子的概念，其中转子的中心PS可以改变，并描述了一种自动识别这种模式的算法。这样可以防止波前破碎和PS附近的碰撞事件不恰当地缩短转子的寿命。我们发现稳定的心外膜转子在VF过程中并不始终存在：17个VF发作中只有1个包含持续4 s整个映射间隔的复合转子。然而，寿命较短的转子很常见。在任何给定的瞬间，在心外膜上都可以看到寿命大于200毫秒的12.2（SD 3.3）复合转子。我们得出的结论是，在该实验模型中，心外膜母亲转子不会驱动VF。如果确实存在母转子，则它们是壁内的或隔膜的。持续转子的缺乏表明单个转子最终将自行终止，因此，不断形成新转子对于VF维护至关重要。

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