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CALL FOR PAPERS ( Physiology and Pharmacology of Temperature Regulation

机译:论文征集(温度调节的生理学和药理学)

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heating and cooling various sites of the preoptic area and anterior hypothalamus (PO/AH) of mammals with fine ther-modes reflexively evoke thermoregulatory responses, indicating that many central thermostats regulate temperature (T) of the brain (16). In PO/AH, heating- and cooling-activated neurons have been recorded in vivo (5, 14) and in vitro (1, 2, 6-8, 10, 12, 20). This suggests that some PO/AH neurons have primary T receptors similar to peripheral T receptors, and that these PO/AH neurons themselves act as the central thermostats (9-11). However, it has been controversial whether primary PO/AH neurons show heating-induced depolarization (6, 12) or not (1, 2, 20). Here, we state that primary PO/AH neurons show heating-induced depolarization based on our study (6) and thermo transient receptor potential (TRP) channels (4, 13, 18, 19)
机译:加热和冷却具有良好温度模式的哺乳动物的视前区和下丘脑前部(PO / AH)的各个部位会自发地引发温度调节反应,表明许多中央恒温器调节着大脑的温度(T)(16)。在PO / AH中,已在体内(5、14)和体外(1、2、6-8、10、12、20)记录了加热和冷却激活的神经元。这表明某些PO / AH神经元具有与外周T受体相似的初级T受体,并且这些PO / AH神经元本身起着中央恒温器的作用(9-11)。然而,原发性PO / AH神经元是否显示出加热引起的去极化(6、12)或没有(1、2、20),一直存在争议。在此,根据我们的研究(6)和热瞬态受体电位(TRP)通道(4、13、18、19),我们声明原发性PO / AH神经元显示出加热引起的去极化

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