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首页> 外文期刊>American Journal of Physiology >Downregulation of AQP2 expression in the kidney of polydipsic STR/N mice.
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Downregulation of AQP2 expression in the kidney of polydipsic STR/N mice.

机译：下调STR / N小鼠肾脏中AQP2表达的下调。

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摘要

Aquaporin-2 (AQP2) is responsible for the concentration of urine in the kidney collecting tubule under the regulation of vasopressin. The mRNA level of this water channel in polydipsic STR/N mice was extremely reduced compared with that in normal ICR mice. In male mice, reduction of the AQP2 mRNA level was not evident at 3 wk of age, at which time water intake was not increased. At 10 wk of age, however, the AQP2 mRNA level was reduced to 10% of that in control mice, whereas water intake was increased by 36%. At 44 wk, the water intake became five times that of the control ICR mice, and the AQP2 mRNA level in these polydipsic mice was only approximately 5% of control. Similar changes were observed in the AQP2 protein level, suggesting that the mRNA level of AQP2 reflects the protein level of AQP2. These inverse changes in the AQP2 mRNA level and water intake were also evident in female mice. The data imply that polydipsia in STR/N mice may have affected AQP2 mRNA transcription in the kidney, resulting in reduced AQP2 expression, which would contribute to a reduction in overretention of water.
机译：在血管加压素的调节下，水通道蛋白2（AQP2）负责肾脏收集管中尿液的浓度。与正常ICR小鼠相比，聚散型STR / N小鼠中该水通道的mRNA水平大大降低。在雄性小鼠中，AQP2 mRNA水平的降低在3周龄时不明显，此时饮水量并未增加。然而，在10周龄时，AQP2 mRNA水平降至对照组小鼠的10％，而饮水量却增加了36％。在第44周时，饮水量变成了对照ICR小鼠的五倍，这些多消化小鼠的AQP2 mRNA水平仅为对照的5％。在AQP2蛋白水平上观察到类似的变化，表明AQP2的mRNA水平反映了AQP2的蛋白水平。在雌性小鼠中，AQP2 mRNA水平和饮水量的这些逆向变化也很明显。数据暗示STR / N小鼠中的多饮可能影响了肾脏中AQP2 mRNA的转录，从而导致AQP2表达降低，这将有助于减少水的过度保留。

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