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首页> 外文期刊>American Journal of Physiology >Compartmental distribution of amino acids during hemodialysis-induced hypoaminoacidemia.
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Compartmental distribution of amino acids during hemodialysis-induced hypoaminoacidemia.

机译：血液透析引起的低氨基酸血症期间氨基酸的区室分布。

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摘要

The intracellular concentrations of essential amino acids (EAA) in muscle are maintained relatively constant under a variety of conditions. However, the effect of a decrease in blood amino acid concentrations on intracellular concentrations is not clear. Similarly, the relation between intracellular and interstitial concentrations has not been determined in this circumstance. Thus the aim of this study was to determine the effect of hypoaminoacidemia on intracellular, interstitial, and plasma concentrations of EAA and the mechanisms responsible for the respective changes. Twelve normal pigs were investigated before and during 120 min of hemodialysis by use of stable-isotope tracer methodology, microdialysis technique, and muscle biopsies. During hemodialysis, there was a decrease in the interstitial fluid concentrations of phenylalanine, leucine, alanine, and lysine that corresponded to their decrease in plasma concentration. Nonetheless, the intracellular concentrations of these amino acids were maintained at the basal levels throughout the entire period due principally to a reduction in the rate of incorporation of amino acids into protein that was approximately equivalent to the decrease in uptake from the plasma. In conclusion, intracellular concentrations of amino acids are regulated to maintain relatively constant values, even when plasma and interstitial concentrations fall as a consequence of hemodialysis.
机译：在各种条件下，肌肉中细胞内必需氨基酸（EAA）的浓度保持相对恒定。但是，血中氨基酸浓度降低对细胞内浓度的影响尚不清楚。类似地，在这种情况下还没有确定细胞内和间质浓度之间的关系。因此，本研究的目的是确定低氨基酸血症对EAA的细胞内，间质和血浆浓度的影响以及引起相应变化的机制。通过使用稳定同位素示踪法，微透析技术和肌肉活检，对十二只正常猪进行血液透析之前和期间的120分钟。血液透析期间，苯丙氨酸，亮氨酸，丙氨酸和赖氨酸的组织液浓度降低，这与血浆浓度降低相对应。尽管如此，这些氨基酸的细胞内浓度在整个时期内都保持在基础水平上，这主要是由于氨基酸向蛋白质中的掺入速率的降低，大约等于血浆中摄取的降低。总之，即使血浆和间质浓度由于血液透析而下降，也可以调节细胞内氨基酸的浓度以保持相对恒定的值。

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