• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension.
【24h】

Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension.

机译：十四烷基硫代乙酸对SHR和2-肾脏，1-夹子高血压的肾素-血管紧张素系统和血压的差异作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The tetradecythioacetic acid (TTA) is a modified fatty acid known to exhibit pleiotropic effects. First, we compared the effect of TTA on the blood pressure in spontaneously hypertensive rats (SHR) with two-kidney, one-clip (2K1C)-hypertensive rats. Second, we examined mechanisms involved in the blood pressure reduction. TTA had minor effect on systolic blood pressure (SBP) in young SHR up to 8 wk of age. In 2K1C we confirmed the blood pressure-lowering effect of TTA (SBP: 173 +/- 4 before vs. 138 +/- 3 mmHg after TTA, P < 0.001). No effect on SBP was seen in Wistar-Kyoto rat (WKY) controls. Plasma renin activity (PRA) was low in SHR and WKY controls and TTA did not change it. PRA decreased from 22.9 +/- 1.3 to 16.2 +/- 2.2 ng.ml(-1).h(-1) (P = 0.02) in 2K1C. Plasma ANG II concentration declined from 101 +/- 3 to 81 +/- 5 fmol/l after TTA treatment (P = 0.005). In the clipped kidney, tissue ANG I concentration decreased from 933 +/- 68 to 518 +/- 60 fmol/g tissue (P = 0.001), and ANG II decreased from 527 +/- 38 to 149 +/- 21 fmol/g tissue (P < 0.001) after TTA treatment. In the nonclipped kidney, TTA did not change ANG I and moderately reduced ANG II levels. The renal blood flow response to injection of ANG II into the nonclipped kidney was blunted compared with controls and normalized with TTA treatment (10 +/- 2 before vs. 20 +/- 2%, P < 0.001). The results indicate that TTA downregulates the renin-angiotensin system in high renin animals but has no effect in low renin models.
机译：十四烷基硫代乙酸（TTA）是一种已知具有多效作用的改性脂肪酸。首先，我们比较了TTA对自发性高血压大鼠（SHR）和两肾一夹（2K1C）高血压大鼠血压的影响。其次，我们研究了降低血压的机制。在8周以下的年轻SHR中，TTA对收缩压（SBP）的影响较小。在2K1C中，我们确认了TTA的降压作用（SBP：TTA之前为173 +/- 4，TTA之后为138 +/- 3 mmHg，P <0.001）。在Wistar-Kyoto大鼠（WKY）对照中未观察到对SBP的影响。在SHR和WKY对照中血浆肾素活性（PRA）较低，而TTA并未改变。在2K1C中，PRA从22.9 +/- 1.3降至16.2 +/- 2.2 ng.ml（-1）.h（-1）（P = 0.02）。 TTA治疗后血浆ANG II浓度从101 +/- 3降至81 +/- 5 fmol / l（P = 0.005）。在截断的肾脏中，组织ANG I的浓度从933 +/- 68降至518 +/- 60 fmol / g组织（P = 0.001），而ANG II的浓度从527 +/- 38降至149 +/- 21 fmol / g TTA处理后的组织（P <0.001）。在非唇肾中，TTA不会改变ANG I并适度降低ANG II水平。与对照组相比，将ANG II注射入未切除的肾脏的肾脏血流反应减弱，并通过TTA治疗使其正常化（之前为10 +/- 2，而之前为20 +/- 2％，P <0.001）。结果表明，TTA在高肾素动物中下调了肾素-血管紧张素系统，但在低肾素模型中没有作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号