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首页> 外文期刊>American Journal of Physiology >Exercise-induced brachial artery vasodilation: role of free radicals.
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Exercise-induced brachial artery vasodilation: role of free radicals.

机译：运动引起的肱动脉血管舒张：自由基的作用。

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Originally thought of as simply damaging or toxic "accidents" of in vivo chemistry, free radicals are becoming increasingly recognized as redox signaling molecules implicit in cellular homeostasis. Indeed, at the vascular level, it is plausible that oxidative stress plays a regulatory role in normal vascular function. Using electron paramagnetic resonance (EPR) spectroscopy, we sought to document the ability of an oral antioxidant cocktail (vitamins C, E, and alpha-lipoic acid) to reduce circulating free radicals, and we employed Doppler ultrasound to examine the consequence of an antioxidant-mediated reduction in oxidative stress on exercise-induced vasodilation. A total of 25 young (18-31 yr) healthy male subjects partook in these studies. EPR spectroscopy revealed a reduction in circulating free radicals following antioxidant administration at rest ( approximately 98%) and as a consequence of exercise ( approximately 85%). Plasma total antioxidant capacity and vitamin C both increased following the ingestion of the antioxidant cocktail, whereas vitamin E levels were not influenced by the ingestion of the antioxidants. Brachial artery vasodilation during submaximal forearm handgrip exercise was greater with the placebo (7.4 +/- 1.8%) than with the antioxidant cocktail (2.3 +/- 0.7%). These data document the efficacy of an oral antioxidant cocktail in reducing free radicals and suggest that, in a healthy state, the aggressive disruption of the delicate balance between pro- and antioxidant forces can negatively impact vascular function. These findings implicate an exercise-induced reliance upon pro-oxidant-stimulated vasodilation, thereby revealing an important and positive vascular role for free radicals.
机译：自由基最初被认为是体内化学物质的简单破坏或有毒“事故”，自由基正越来越多地被认为是细胞稳态中隐含的氧化还原信号分子。确实，在血管水平上，氧化应激在正常血管功能中起调节作用是合理的。我们使用电子顺磁共振（EPR）光谱，试图证明口服抗氧化剂混合物（维生素C，E和α-硫辛酸）减少循环自由基的能力，并采用多普勒超声检查抗氧化剂的结果介导的运动诱发的血管舒张时氧化应激的降低。共有25名年轻（18-31岁）健康男性受试者参加了这些研究。 EPR光谱显示，在静息状态下进行抗氧化剂给药后，循环自由基的减少（约98％），并且由于运动而减少了循环自由基（约85％）。摄入抗氧化剂混合物后，血浆总抗氧化能力和维生素C均增加，而维生素E的水平不受摄入抗氧化剂的影响。安慰剂组（7.4 +/- 1.8％）的最大前臂握力锻炼过程中肱动脉血管舒张作用大于抗氧化剂混合物（2.3 +/- 0.7％）。这些数据证明了口服抗氧化剂混合物在减少自由基方面的功效，并表明，在健康状态下，积极破坏抗氧化剂和抗氧化剂之间的微妙平衡会严重破坏血管功能。这些发现暗示了运动诱导的对氧化剂刺激的血管舒张的依赖，从而揭示了自由基对血管的重要作用。

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