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首页> 外文期刊>American Journal of Physiology >Role of acetaminophen in acute myocardial infarction.
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Role of acetaminophen in acute myocardial infarction.

机译：对乙酰氨基酚在急性心肌梗死中的作用。

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Acetaminophen, the active ingredient in Tylenol, is a widely used drug that is well known for its analgesic and antipyretic properties. Acetaminophen is a commonly used alternative to nonsteroidal anti-inflammatory drugs, which have recently been demonstrated to increase mortality after acute myocardial infarction (AMI). The safety and potential cardioprotective properties of acetaminophen in the setting of AMI have recently been investigated; however, the results from these studies have been inconclusive. Using both large (ovine) and small (rabbit) collateral-deficient animal models, we studied the effects of acetaminophen in the setting of reperfused AMI. In both species we studied the effects of acetaminophen on myocardial salvage and ventricular function. Additionally, we studied the effects of acetaminophen on myocardial perfusion in sheep and on myocyte apoptosis in rabbits. Sixteen sheep and twenty-two rabbits were divided into two groups and administered acetaminophen or a vehicle before undergoing ischemia and reperfusion. The ischemic period was 60 min in sheep and 30 min in rabbits. All animals were reperfused for 3 h. There were no significant differences observed in myocardial perfusion, myocyte apoptosis, or infarct size in acetaminophen-treated animals. Acetaminophen increased cardiac output and mean arterial pressure before ischemia in sheep but had no effect on any other hemodynamic parameter. In rabbits, no effect on cardiac output or blood pressure was detected. These results support the role of acetaminophen as a safe drug in the postmyocardial infarction setting; however, no significant cardioprotective effect of the drug could be demonstrated.
机译：扑热息痛是泰诺的活性成分，是一种广泛使用的药物，以其止痛和解热作用而闻名。对乙酰氨基酚是非甾体类抗炎药的常用替代品，最近已证明对乙酰氨基酚会增加急性心肌梗塞（AMI）后的死亡率。对乙酰氨基酚在急性心肌梗死中的安全性和潜在的心脏保护性能最近进行了研究。然而，这些研究的结果尚无定论。使用大型（绵羊）和小型（兔子）附带缺陷动物模型，我们研究了对乙酰氨基酚在再灌注AMI中的作用。在这两个物种中，我们研究了对乙酰氨基酚对心肌抢救和心室功能的影响。此外，我们研究了对乙酰氨基酚对绵羊心肌灌注和兔子心肌细胞凋亡的影响。将16只绵羊和22只兔子分成两组，在进行缺血和再灌注之前，先给予对乙酰氨基酚或媒介物。绵羊的缺血期为60分钟，兔子的为30分钟。将所有动物再灌注3小时。在对乙酰氨基酚治疗的动物中，心肌灌注，心肌细胞凋亡或梗死面积无明显差异。对乙酰氨基酚可增加绵羊缺血后的心排血量和平均动脉压，但对任何其他血液动力学参数均无影响。在兔子中，未检测到对心输出量或血压的影响。这些结果支持了对乙酰氨基酚作为心肌梗死后安全药物的作用。但是，该药物没有明显的心脏保护作用。

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