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首页> 外文期刊>American Journal of Physiology >Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes.
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Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes.

机译：吡啶斯的明抑制乙酰胆碱酯酶对久坐的成年人和训练有素的运动员心脏副交感神经功能的影响。

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摘要

Heart rate variability and postexercise heart rate recovery are used to assess cardiac parasympathetic tone in human studies, but in some cases these indexes appear to yield discordant information. We utilized pyridostigmine, an acetylcholinesterase inhibitor that selectively augments the parasympathetic efferent signal, to further characterize parasympathetic regulation of rest and postexercise heart rate. We measured time- and frequency-domain indexes of resting heart rate variability and postexercise heart rate recovery in 10 sedentary adults and 10 aerobically trained athletes after a single oral dose of pyridostigmine (30 mg) and matching placebo in randomized, double-blind, crossover trial. In sedentary adults, pyridostigmine decreased resting heart rate [from 66.7 (SD 12.6) to 58.1 beats/min (SD 7.6), P = 0.005 vs. placebo] and increased postexercise heart rate recovery at 1 min [from 40.7 (SD 10.9) to 45.1 beats/min (SD 8.8), P = 0.02 vs. placebo]. In trained athletes, pyridostigmine did not change resting heart rate or postexercise heart rate recovery when compared with placebo. Time- and frequency-domain indexes of resting heart rate variability did not differ after pyridostigmine versus placebo in either cohort and were not significantly associated with postexercise heart rate recovery in either cohort. The divergent effects of pyridostigmine on resting and postexercise measures of cardiac parasympathetic function in sedentary subjects confirm that these measures characterize distinct aspects of cardiac parasympathetic regulation. The lesser effect of pyridostigmine on either measure of cardiac parasympathetic tone in the trained athletes indicates that the enhanced parasympathetic tone associated with exercise training is at least partially attributable to adaptations in the efferent parasympathetic pathway.
机译：在人类研究中，心率变异性和运动后心率恢复被用于评估心脏副交感神经张力，但在某些情况下，这些指数似乎产生不一致的信息。我们利用吡ido斯的明（一种选择性增强副交感神经传出信号的乙酰胆碱酯酶抑制剂）来进一步表征交感神经调节的休息和运动后心率。我们在随机，双盲，交叉试验中口服吡ido斯的明（30 mg）和匹配的安慰剂后，测量了10位久坐的成年人和10位有氧运动训练的运动员的静息心率变异性和运动后心率恢复的时域和频域指标。试用。在久坐的成年人中，吡啶斯的明降低静息心率[从66.7（SD 12.6）到58.1节拍/分钟（SD 7.6），与安慰剂相比P = 0.005]，并且在运动后1分钟的心率恢复增加[从40.7（SD 10.9）降至45.1次/分钟（SD 8.8），相对于安慰剂，P = 0.02]。在训练有素的运动员中，吡啶斯的明与安慰剂相比没有改变静息心率或运动后心率恢复。吡啶斯的明与安慰剂相比，静息心率变异性的时域和频域指标在两个队列中均无差异，并且与两个队列中的运动后心率恢复均无显着相关性。吡啶斯的明对久坐受试者的心脏副交感神经功能的休息和运动后措施的分歧作用证实，这些措施表征了心脏副交感神经调节的不同方面。吡啶斯的明对受训运动员心脏副交感神经张力的两种测量值的较小影响表明，与运动训练相关的副交感神经张力增强至少部分归因于传出的副交感神经通路的适应性。

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