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首页> 外文期刊>American Journal of Physiology >How muscle insulin sensitivity is regulated: testing of a hypothesis.
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How muscle insulin sensitivity is regulated: testing of a hypothesis.

机译：如何调节肌肉胰岛素敏感性：检验假设。

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Muscle contractions induce an increase in glucose transport. The acute effect of muscle contractions on glucose transport is independent of insulin and reverses rapidly after cessation of exercise. As the acute increase in glucose transport reverses, a marked increase in the sensitivity of muscle to insulin occurs. The mechanism for this phenomenon is unknown. We hypothesize that an increase in insulin sensitivity is a general phenomenon that occurs during reversal of an increase in cell surface GLUT4 induced by any stimulus, not just exercise. To test this hypothesis, epitrochlearis, rat soleus, and flexor digitorum brevis muscles were incubated for 30 min with a maximally effective insulin concentration (1.0 mU/ml). Muscles were allowed to recover for 3 h in the absence of insulin. Muscles were then exposed to 60 microU/ml insulin for 30 min followed by measurement of glucose transport. Preincubation with 1.0 mU/ml insulin resulted in an approximately 2-fold greater increase in glucose transport 3.5 h later in response to 60 microU/ml insulin than that which occurred in control muscles treated with 60 microU/ml insulin. Pretreatment of muscles with combined maximal insulin and exercise stimuli greatly amplified the increase in insulin sensitivity. The increases in glucose transport were paralleled by increases in cell surface GLUT4. We conclude that stimulation of glucose transport by any agent is followed by an increase in sensitivity of glucose transport to activation that is mediated by translocation of more GLUT4 to the cell surface.
机译：肌肉收缩导致葡萄糖转运增加。肌肉收缩对葡萄糖转运的急性作用与胰岛素无关，并且在运动停止后迅速逆转。随着葡萄糖转运的急剧增加逆转，肌肉对胰岛素的敏感性显着增加。这种现象的机制尚不清楚。我们假设胰岛素敏感性的升高是一种普遍现象，这种现象是由任何刺激（不仅仅是运动）引起的细胞表面GLUT4升高的逆转过程中发生的。为了验证该假设，将上tro肌，大鼠比目鱼肌和短指屈肌与最大有效胰岛素浓度（1.0 mU / ml）孵育30分钟。在不存在胰岛素的情况下使肌肉恢复3小时。然后将肌肉暴露于60 microU / ml胰岛素中30分钟，然后测量葡萄糖转运。用1.0 mU / ml胰岛素进行预温育后，对60 microU / ml胰岛素的反应在3.5 h后的葡萄糖转运增加了约2倍，而在用60 microU / ml胰岛素处理的对照肌肉中发生的增加。结合最大胰岛素和运动刺激对肌肉进行预处理可大大增强胰岛素敏感性的增加。葡萄糖转运的增加与细胞表面GLUT4的增加平行。我们得出结论，任何试剂刺激葡萄糖转运后，葡萄糖转运对激活的敏感性增加，这是由更多GLUT4易位到细胞表面介导的。

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