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首页> 外文期刊>American Journal of Physiology >Adequate oral threonine is critical for mucin production and gut function in neonatal piglets.
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Adequate oral threonine is critical for mucin production and gut function in neonatal piglets.

机译：充足的口服苏氨酸对新生仔猪的粘蛋白产生和肠道功能至关重要。

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In previous experiments, we found that the threonine requirement of neonatal piglets fed parenterally was 40% of that when fed intragastrically; we hypothesized that much of the oral supply of threonine is being used for mucin production. To investigate this hypothesis, intragastrically fed 2-day-old piglets were fed one of three treatments for 8 days: 1) a threonine-adequate diet (IG-A; 0.6 g threonine.kg(-1).day(-1) fed intragastrically); 2) a threonine-deficient diet (IG-D; 0.1 g threonine.kg(-1).day(-1) fed intragastrically); or 3) a threonine-deficient diet with adequate threonine delivered parenterally (IV-A; 0.5 g threonine.kg(-1).day(-1) fed parenterally plus 0.1 g threonine.kg(-1).day(-1) fed intragastrically). IG-D piglets experienced higher nitrogen excretion, higher plasma urea, and lower plasma threonine concentrations versus both of the other groups (P < 0.05), indicating profound threonine deficiency. Mucosal mass and total crude mucin content were lower in the colons of IG-D pigs (P < 0.05). Histopathological analysis showed lower numbers of acidic mucin-producing goblet cells in the duodenum and ileum of IG-D pigs. In IG-D pigs, acidic mucin subtypes were lower in the small intestine but higher in the colon, which corresponded with persistent diarrhea. The parenteral supply of threonine was adequate to maintain most outcome parameters, although IV-A pigs did have smaller colonic goblet cells with more acidic mucins compared with IG-A pigs. Overall, our results suggest that adequate dietary threonine was critical in the production of mucus and that a parenteral threonine supply can ameliorate most of the symptoms of oral threonine deficiency.
机译：在以前的实验中，我们发现肠胃外喂养的新生仔猪的苏氨酸需求量为胃内喂养时的苏氨酸需求量的40％。我们假设苏氨酸的口服供应大部分用于粘蛋白生产。为了研究该假设，将胃内喂养的2天大的仔猪喂食3种处理之一，持续8天：1）苏氨酸充足的日粮（IG-A; 0.6 g苏氨酸.kg（-1）.day（-1）胃内喂养）; 2）苏氨酸缺乏饮食（IG-D;胃内喂养的苏氨酸0.1 g.kg（-1）.day（-1））;或3）非苏氨酸的饮食，需经肠胃外给予足够的苏氨酸（IV-A;经肠胃外喂养的0.5 g苏氨酸.kg（-1）.day（-1）加0.1 g苏氨酸.kg（-1）.day（-1） ）。与其他两组相比，IG-D仔猪排泄的氮更高，血浆尿素更高，血浆苏氨酸浓度更低（P <0.05），表明苏氨酸严重缺乏。 IG-D猪结肠的粘膜质量和总粗粘蛋白含量较低（P <0.05）。组织病理学分析显示，IG-D猪十二指肠和回肠中产生酸性粘蛋白的杯状细胞数量减少。在IG-D猪中，酸性粘蛋白亚型在小肠中较低，而在结肠中较高，这与持续腹泻相对应。尽管IV-A猪确实比IG-A猪具有更小的结肠杯状细胞和更多的酸性粘蛋白，但肠胃外供应的苏氨酸足以维持大多数结果参数。总体而言，我们的结果表明，充足的饮食苏氨酸对粘液的产生至关重要，肠胃外提供的苏氨酸可以缓解口服苏氨酸缺乏的大多数症状。

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