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首页> 外文期刊>American Journal of Physiology >Transforming growth factor-beta in the brain is activated by exercise and increases mobilization of fat-related energy substrates in rats.
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Transforming growth factor-beta in the brain is activated by exercise and increases mobilization of fat-related energy substrates in rats.

机译：大脑中的转化生长因子β通过运动被激活，并增加了大鼠脂肪相关能量底物的动员。

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We have recently reported that inhibition of transforming growth factor (TGF)-beta in the brain reduced fat-related energy substrates concentrations in response to exercise. We investigated the relevance between the mobilization of fat-related energy substrates (nonesterified fatty acid and ketone bodies) during exercise and the effects of TGF-beta in the brain. Low-intensity exercise was simulated by contraction of the hindlimbs, induced by electrical stimulation at 2 Hz in anesthetized rats (Sim-Ex). As with actual exercise, it was confirmed that mobilization of carbohydrate-related energy substrates (glucose and lactic acid) occurred immediately after the onset of Sim-Ex, and mobilization of fat-related energy substrates followed thereafter. The timing of mobilization of fat-related substrates corresponded to that of the increase in TGF-beta in cerebrospinal fluid (CSF) in Sim-Ex. The level of TGF-beta in CSF significantly increased after 10 min of Sim-Ex and remained elevated until 30 min of Sim-Ex. Intracisternal administration of TGF-beta caused rapid mobilization of fat-related energy substrates. Meanwhile, there were no effects on the changes in carbohydrate-related substrates. The levels of catecholamines were slightly elevated after TGF-beta administration, and, although not significantly in statistical terms, we consider that at least a part of TGF-beta signal was transducted via the sympathetic nervous system because of these increases. These data indicate that TGF-beta in the brain is closely related to the mobilization of fat-related energy substrates during low-intensity exercise. We hypothesized that the central nervous system plays a role in the regulation of energy metabolism during low-intensity exercise and this may be mediated by TGF-beta.
机译：最近，我们报道了大脑对转化生长因子（TGF）-β的抑制作用降低了与运动有关的脂肪相关能量底物的浓度。我们调查了运动期间与脂肪相关的能量底物（非酯化脂肪酸和酮体）的动员与TGF-β在大脑中的作用之间的相关性。低强度运动是通过麻醉大鼠（Sim-Ex）在2 Hz电刺激引起的后肢收缩来模拟的。与实际锻炼一样，已证实在Sim-Ex发作后立即发生了与碳水化合物有关的能量底物（葡萄糖和乳酸）的动员，此后又进行了与脂肪有关的能量底物的动员。脂肪相关底物的动员时间与Sim-Ex中脑脊液（CSF）中TGF-β升高的时间相对应。 Sim-Ex 10分钟后，脑脊液中TGF-β的水平显着增加，直到Sim-Ex 30分钟后，TGF-β的水平仍保持升高。颅内注射TGF-β引起脂肪相关能量底物的快速动员。同时，对碳水化合物相关底物的变化没有影响。施用TGF-β后儿茶酚胺的水平略有升高，尽管在统计学上没有显着提高，但由于这些增加，我们认为TGF-β信号的至少一部分是通过交感神经系统传导的。这些数据表明，在低强度运动中，大脑中的TGF-β与脂肪相关能量底物的动员密切相关。我们假设中枢神经系统在低强度运动过程中的能量代谢调节中起作用，这可能是由TGF-β介导的。

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