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Contraceptive efficacy of emergency contraception with levonorgestrel given before or after ovulation.

机译：排卵之前或之后给予左炔诺孕酮紧急避孕的避孕效果。

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BACKGROUND: We aimed to evaluate whether emergency contraception with levonorgestrel (LNG-EC) administered after ovulation is equally effective to LNG-EC administered before ovulation. STUDY DESIGN: We studied a cohort of women attending a family planning clinic for EC. From interview, we recorded menstrual history, time of intercourse and of intake of LNG-EC. On the day of intake of LNG-EC and during 5 days' follow-up, blood samples were taken for examination of luteinizing hormone, estradiol and progesterone concentrations, and vaginal ultrasound examinations were done for size of the leading follicle and/or corpus luteum. Thereafter women were not contacted until next menses or pregnancy occurred. RESULTS: Of 388 women attending for LNG-EC, 122 women had intercourse on fertile cycle days according to ultrasound and endocrine findings. At the time of LNG-EC intake, 87 women were in Days -5 to -1 and 35 women were in Day 0 (day of ovulation) or beyond. With the use of the probability of clinical pregnancy reported by Wilcox et al. [N Engl J Med 333 (1995) 1517-1521], expected numbers of pregnancies among the 87 and 35 women were 13 and 7, respectively, while 0 and 6 pregnancies, respectively, occurred. CONCLUSION: We conclude that LNG-EC prevents pregnancy only when taken before fertilization of the ovum has occurred.
机译：背景：我们旨在评估排卵后给予左炔诺孕酮（LNG-EC）的紧急避孕药与排卵前给予LNG-EC是否同样有效。研究设计：我们研究了一群参加EC计划生育诊所的妇女。从访谈中，我们记录了月经史，性交时间和LNG-EC的摄入量。在摄取LNG-EC的当天和5天的随访期间，采集血液样本检查黄体生成素，雌二醇和孕酮的浓度，并进行阴道超声检查以检查前导卵泡和/或黄体的大小。 。此后直到下一次月经或怀孕才接触妇女。结果：根据超声和内分泌结果，在参加LNG-EC的388名妇女中，有122名妇女在生育周期中进行了性交。在摄入LNG-EC时，第5天至-1天有87名妇女，而在第0天（排卵日）或以后有35名妇女。随着威尔科克斯等人报道的临床妊娠的可能性。 [N Engl J Med 333（1995）1517-1521]，在87名和35名妇女中，预期怀孕的人数分别为13和7名，而分别发生0和6次怀孕。结论：我们得出结论，只有在卵子受精前服用LNG-EC才能阻止怀孕。

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