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首页> 外文期刊>Contraception >A randomized pilot study on the effectiveness and side-effect profiles of two doses of digoxin as fetocide when administered intraamniotically or intrafetally prior to second-trimester surgical abortion.
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A randomized pilot study on the effectiveness and side-effect profiles of two doses of digoxin as fetocide when administered intraamniotically or intrafetally prior to second-trimester surgical abortion.

机译：一项随机的先导研究，研究了在中期妊娠流产前羊膜腔内或胎儿内注射两剂地高辛作为杀虫剂的有效性和副作用。

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BACKGROUND: Digoxin is commonly used to facilitate second-trimester surgical abortion despite limited data regarding its safety and effectiveness for this indication. We conducted a pilot study to determine the incidence of side effects after digoxin administration and whether effectiveness can be improved with variations in dose and technique. STUDY DESIGN: Fifty-two women presenting for elective termination of pregnancy between 18 and 24 weeks' gestation were randomized to one of four digoxin treatment groups: 1.0 mg intraamniotic (1.0 IA), 1.0 mg intrafetal (1.0 IF), 1.5 mg intraamniotic (1.5 IA) or 1.5 mg intrafetal (1.5 IF). Ultrasound was used to assess for the presence of fetal cardiac activity prior to the abortion procedure. Data on the presence and severity of pain, nausea and other potential side effects were collected before digoxin injection, immediately following digoxin injection and on the day after digoxin injection. RESULTS: Digoxin effectively induced fetal death in 87% of women. The failure rate did not vary by route of administration (IA or IF) and was not lowered by increasing the dose from 1.0 to 1.5 mg. IF injections induced fetal death more rapidly than IA injections. Digoxin administration did not result in increased pain or nausea. CONCLUSIONS: IA or IF injection of digoxin is safe and effective for inducing fetal death prior to second-trimester surgical abortion. Doses greater than 1.0 mg may not be necessary.
机译：背景：地高辛通常用于促进中孕期手术流产，尽管有关该适应症的安全性和有效性的数据有限。我们进行了一项初步研究，以确定地高辛给药后的副作用发生率以及剂量和技术的变化是否可以提高疗效。研究设计：52名在妊娠18-24周之间择期终止妊娠的妇女被随机分为四个地高辛治疗组之一：1.0 mg羊膜内注射（1.0 IA），1.0 mg胎儿内注射（1.0 IF），1.5 mg羊膜内注射（1.0 mg）。 1.5 IA）或1.5 mg胎儿内（1.5 IF）。在流产手术之前，使用超声来评估胎儿心脏活动的存在。在注射地高辛之前，注射地高辛之后以及注射地高辛后的第二天，收集有关疼痛，恶心和其他潜在副作用的存在和严重程度的数据。结果：地高辛有效地诱导了87％的妇女死亡。失败率并未随给药途径（IA或IF）而变化，并且未通过将剂量从1.0毫克增加至1.5毫克而降低。 IF注射比IA注射更快地诱发胎儿死亡。地高辛的使用并未导致疼痛或恶心加重。结论IA或IF注射地高辛可安全有效地诱导中期妊娠流产前的胎儿死亡。剂量可能不需要大于1.0 mg。

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