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首页> 外文期刊>American Journal of Physiology >Hypoxic ventilatory response during light and dark periods and the involvement of histamine H1 receptor in mice.
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Hypoxic ventilatory response during light and dark periods and the involvement of histamine H1 receptor in mice.

机译：小鼠在黑暗和黑暗时期的低氧通气反应以及组胺H1受体的参与。

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Ventilation oscillates throughout a day in parallel with oscillations in metabolic rate. Histamine affects ventilation and the balance of the energy metabolism via H1 receptors in the brain. We tested the hypothesis that the ventilatory response to hypoxia varies between light and dark periods and that histamine H1 receptors are required for the circadian variation, using wild-type (WT) and histamine H1 receptor knockout (H1RKO) mice. Mice were exposed to hypoxic gas (7% O(2) + 3% CO(2) in N(2)) during light and dark periods. Ventilation initially increased and then declined. In WT mice, minute ventilation (.Ve) during hypoxia was higher in the dark period than in the light period, which was an upward shift along with the baseline ventilation. Hypoxia decreased the metabolic rate, whereas O2 consumption (.VO(2)) and CO(2) excretion were higher in the dark period than in the light period. However, in H1RKO mice, changes in Ve during hypoxia between light and dark periods were minimal, because .Ve was increased relative to .VO(2), particularly in the light period. In H1RKO mice, the HCO(3)(-) concentration and base excess values were increased in arterial blood, and the level of ketone bodies was increased in the serum, indicating that metabolic acidosis occurred. Respiratory compensation takes part in the .Ve increase relative to .VO(2) during hypoxia. These results suggested that changes in .Ve during hypoxia vary between light and dark periods and that H1 receptors play a role in circadian variation in .Ve through control of the acid-base status and metabolism in mice.
机译：通气一天全天都在振荡，而新陈代谢速率则在不断波动。组胺通过大脑中的H1受体影响通气和能量代谢的平衡。我们测试了以下假设：使用野生型（WT）和组胺H1受体敲除（H1RKO）小鼠，对缺氧的通气反应在明暗期间有所不同，并且昼夜节律变化需要组胺H1受体。在明亮和黑暗的时期，小鼠暴露于低氧气体（7％O（2）+ 3％CO（2）在N（2）中）。通风最初增加，然后下降。在野生型小鼠中，缺氧时的分钟通气量（.Ve）在黑暗时期要比在明亮时期高，这与基线通气一起向上移动。缺氧降低了代谢率，而在黑暗时期的氧气消耗量（.VO（2））和CO（2）的排泄量高于在明亮时期。但是，在H1RKO小鼠中，缺氧期间在黑暗和黑暗时期之间的Ve变化很小，因为相对于.VO（2），. Ve有所增加，尤其是在明亮时期。在H1RKO小鼠中，动脉血中的HCO（3）（-）浓度和碱基过量值增加，血清中酮体的水平增加，表明发生了代谢性酸中毒。在缺氧期间，呼吸补偿相对于.VO（2）参与.Ve的增加。这些结果表明，缺氧期间.Ve的变化在黑暗和黑暗期间有所不同，并且H1受体通过控制小鼠的酸碱状态和代谢而在.Ve的昼夜节律变化中起作用。

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