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首页> 外文期刊>Cortex: A Journal Devoted to the Study of the Nervous System and Behavior >Central and peripheral agraphia in Alzheimer's disease: from the case of Auguste D. to a cognitive neuropsychology approach.
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Central and peripheral agraphia in Alzheimer's disease: from the case of Auguste D. to a cognitive neuropsychology approach.

机译：阿尔茨海默氏病的中央和周围的书写障碍：从奥古斯特·D。（Auguste D.）到认知神经心理学方法。

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Since the observation of Auguste D. by Alois Alzheimer, it is an acknowledged fact that writing is one of the cognitive functions that are weakened early in Alzheimer's disease (AD). This study aimed to examine the cognitive nature of this disorder and question the hypothesis of a standard progression (Platel et al., 1993) from lexical to other central and more peripheral processes. A large group of mild to moderate AD patients (n=59) and a group of healthy elderly controls were submitted to an extensive assessment of both the central and peripheral components of writing. A comparison of groups indicated that AD patients performed more poorly than controls on a wide range of writing measures. It revealed a predominantly lexical disorder, but also found evidence of associated disorders located at different stages in the spelling system (phonological route, graphemic buffer, allographic store, graphic motor patterns). A multiple single-case analysis, using a specific methodology, allowed us to delimit individual profiles of agraphia. It revealed a wide variety of agraphia syndromes, including a far from negligible number of patients with selective damage to one of the central or peripheral components, as well as patients with multiple writing impairments. A positive correlation was observed between the severity of the dementia and spelling/writing measures (lexical and allographic). This study does not support the hypothesis of a uniform progression. Rather, it points to heterogeneous profiles of agraphia and suggests that the first signs of writing impairment in AD stem from changes at different points in the broad anatomical network subserving spelling and writing abilities.
机译：自Alois Alzheimer观察到Auguste D.以来，公认的事实是写作是在Alzheimer病（AD）早期减弱的一种认知功能。这项研究的目的是检查这种疾病的认知性质，并质疑从词法到其他中心过程以及更多外围过程的标准进展的假说（Platel等，1993）。一大批轻度至中度AD患者（n = 59）和一组健康的老年对照者接受了对写作中枢和外围成分的广泛评估。各组之间的比较表明，AD患者在广泛的书写方式上的表现比对照组要差。它揭示了一个主要的词汇障碍，但也发现了在拼写系统的不同阶段（语音路径，字形缓冲，字母存储，图形运动模式）相关障碍的证据。使用一种特定的方法进行多次单例分析，使我们能够划定笔迹的个人特征。它揭示了各种各样的失语症候群，其中包括对中央或外周成分之一有选择性损害的患者，远不及可忽略的人数，以及患有多种书写障碍的患者。痴呆症的严重程度与拼写/书写方式（词汇和字法）之间呈正相关。该研究不支持统一进展的假设。而是，它指出了笔迹的异质性，并暗示了AD书写障碍的最初迹象来自于在广泛的解剖网络中保留了拼写和书写能力的不同点的变化。

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