Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits.

Kayani AC; Close GL; Jackson MJ

首页> 外文期刊>American Journal of Physiology >Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits.

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Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits.

机译：长时间的跑步机训练会增加骨骼肌中的HSP70，但不会影响与年龄相关的功能缺陷。

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Skeletal muscle atrophy and weakness are major causes of frailty in the elderly. Functional deficits in muscles of old humans and rodents are associated with attenuated production of heat shock proteins (HSPs) after exercise, and transgenic overexpression of HSP70 reverses this functional decline. We hypothesized that training would increase HSP70 content of muscle in adult and old wild-type mice and that this would protect against the development of age-related functional deficits. A 10-wk treadmill training protocol at 15 m/min, for 15 min, 3 days/wk resulted in a significant increase in HSP70 content of muscles of adult mice. Muscles of old untrained mice demonstrated a significant increase in HSP70 protein content and a reduction in HSP70 mRNA content compared with adult untrained mice. Training for 12 mo starting at age 12-14 mo old or for 10 wk starting from age 24 mo old resulted in modification of HSP70 protein and mRNA content to levels of adult mice. Training did not change force generation of extensor digitorum longus muscles of old mice or improve recovery after damaging contractions. The twofold increase in HSP70 content in muscles of adult mice after training may have not been sufficient to provide protection in this instance.

机译：骨骼肌萎缩和无力是老年人衰弱的主要原因。老年人和啮齿动物肌肉的功能缺陷与运动后热休克蛋白（HSP）的产生减弱有关，HSP70的转基因过表达逆转了这种功能下降。我们假设训练将增加成年和成年野生型小鼠肌肉的HSP70含量，并且这将防止与年龄相关的功能缺陷的发展。 10 wk跑步机训练方案以15 m / min的速度连续15分钟，3天/周，导致成年小鼠肌肉中HSP70含量显着增加。与成年未经训练的小鼠相比，未经训练的老小鼠的肌肉表现出HSP70蛋白含量的显着增加和HSP70 mRNA含量的降低。从12-14岁开始训练12个月，或从24岁开始训练10周，导致HSP70蛋白和mRNA含量改变至成年小鼠水平。训练并没有改变老小鼠的指伸长肌的力量产生，也没有改善损伤性收缩后的恢复。训练后成年小鼠肌肉中HSP70含量的两倍增加可能不足以在这种情况下提供保护。

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《American Journal of Physiology》 |2008年第2期|共9页
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Kayani AC; Close GL; Jackson MJ;
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1. Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits. [J] . Kayani AC, Close GL, Jackson MJ American Journal of Physiology . 2008,第2aPta2期

机译：长时间的跑步机训练会增加骨骼肌中的HSP70，但不会影响与年龄相关的功能缺陷。
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机译：增加休息肌僵硬，较少被认为是年龄相关的骨骼肌损伤的组分

Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits.

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