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Pressure-distension relationship in arteries and arterioles in response to 5 of horizontal bedrest

机译：卧床5对动脉和小动脉的压力-膨胀关系

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First published July 25, 2008; doi:10.1152/ajpheart00576.2008.-We hypothesized that exposure to prolonged recumbency (bedrest), and thus reductions of intravascular pressure gradients, increases pressure distension in arteries/arterioles in the legs. Ten subjects underwent 5 wk of horizontal bedrest. Pressure distension was investigated in arteries and arterioles before and after the bedrest, with the subject seated or supine in a hyperbaric chamber with either one arm or a lower leg protruding through a hole in the chamber door. Increased pressure in the vessels of the arm/leg was accomplished by increasing chamber pressure. Vessel diameter and flow were measured in the brachial and posterior tibial arteries using Doppler ultrasonography. Electrical tissue impedance was measured in the test limb. Bedrest increased (P < 0.01) pressure distension threefold in the tibial artery (from 8 +-7% to 24 +- 11%) and by a third (P < 0.05) in the brachial artery (from 15 +- 9% to 20 +- 10%). The pressure-induced increase in tibial artery flow was more pronounced {P < 0.01) after (50 +- 39 ml/rnin) than before (13 +- 23 ml/min) bedrest, whereas the brachial artery flow response was unaffected by bedrest. The pressure-induced decrease in tissue impedance in the leg was more pronounced (P < 0.01) after (16 +- 7%) than before (10 +- 6%) bedrest, whereas bedrest did not affect the impedance response in the arm. Thus, withdrawal of the hydrostatic pressure gradients that act along the blood vessels in erect posture markedly increases pressure distension in dependent arteries and arterioles.
机译：2008年7月25日首次发布; doi：10.1152 / ajpheart00576.2008.-我们假设长时间卧卧（卧床休息），从而降低血管内压力梯度，会增加腿部动脉/小动脉的压力膨胀。十名受试者水平卧床休息5周。在卧床休息之前和之后，对动脉和小动脉的压力膨胀进行了研究，受试者坐在或仰卧在高压舱中，一只手臂或小腿穿过舱门的一个孔伸出。通过增加腔室压力来实现手臂/腿部血管中压力的增加。使用多普勒超声检查在肱动脉和胫后动脉中的血管直径和流量。在测试肢中测量组织电阻抗。卧床休息使胫动脉中的压力膨胀增加（P <0.01）三倍（从8 + -7％增至24 +-11％），而肱动脉中的压力膨胀增加了三分之一（P <0.05）（从15 +-9％至20 +-10％）。卧床休息（50 +-39 ml / min）后，压力诱发的胫动脉流量增加更为明显（P <0.01），而卧床休息之前（13 +-23 ml / min），肱动脉流量响应不受卧床影响。卧床休息后（16±7％），压力引起的腿部组织阻抗的降低更为明显（P <0.01），而卧床休息前（10±6％）则没有影响手臂的阻抗响应。因此，以竖立姿势沿着血管起作用的静水压力梯度的撤消明显增加了从属动脉和小动脉的压力膨胀。

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