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首页> 外文期刊>American Journal of Physiology >Astrocytes are a key conduit for upstream signaling of vasodilation during cerebral cortical neuronal activation in vivo.
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Astrocytes are a key conduit for upstream signaling of vasodilation during cerebral cortical neuronal activation in vivo.

机译：星形胶质细胞是体内大脑皮层神经元激活过程中血管舒张上游信号的关键管道。

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摘要

Astrocytes play an important role in the coupling between neuronal activity and brain blood flow via their capacity to "sense" neuronal activity and transmit that information to parenchymal arterioles. Here we show another role for astrocytes in neurovascular coupling: the ability to act as a signaling conduit for the vitally important process of upstream vasodilation (represented by pial arterioles) during both excessive (seizure) and physiological (sciatic nerve stimulation) increases in cerebral cortical neuronal activity. The predominance of an astrocytic rather than a vascular route was indicated by data showing that pial arteriolar-dilating responses to neuronal activation were completely blocked following selective disruption of the superficial glia limitans, whereas interference with interendothelial signaling was without effect. Results also revealed contributions from connexin 43, implying a role for gap junctions and/or hemichannels in the signaling process and that signaling from the glia limitans to pial arterioles may involve a diffusible mediator.
机译：星形胶质细胞通过“感知”神经元活性并将信息传递给实质小动脉的能力，在神经元活性与脑血流之间的耦合中起重要作用。在这里，我们显示了星形胶质细胞在神经血管耦合中的另一个作用：在大脑皮层过度（癫痫发作）和生理性（坐骨神经刺激）过程中，充当上游血管扩​​张（以小动脉小动脉为代表）这一至关重要过程的信号传导通道的能力增强神经元活动。有数据显示，星形胶质细胞而非血管途径占优势，表明选择性地破坏浅表神经胶质限脂后，对神经元活化的小动脉扩张反应被完全阻断，而对内皮间信号传导的干扰没有作用。结果还揭示了连接蛋白43的作用，这暗示了间隙连接和/或半通道在信号传导过程中的作用，并且从神经胶质限脂到唾液小动脉的信号传导可能涉及扩散介质。

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