Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1

Jun-Te Hsu; Wen-Hong Kan; Chi-Hsun Hsieh; Mashkoor A. Choudhry; Martin G. Schwacha

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Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1

机译：创伤性出血后雌激素介导的肠道保护机制：HO-1的p38 MAPK依赖性上调

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An increasing body of evidence shows that p38 MAPK activation leads to the induction of heme oxygenase (HO)-l (10, 37). HO-1 confers protection against oxidative stress in vivo and in vitro, through antioxidative, antiapoptotic, and anti-inflammatory actions (26, 27). Exogenous administration of HO-1 by gene transfer into rat lung mediates potent anti-inflammatory effects in the lung (27). Moreover, overexpres-sion of HO-1 reduces the expression of adhesion molecules and prevents subsequent leukocyte-endothelial cell interactions and organ damage (32, 38).

机译：越来越多的证据表明p38 MAPK激活导致血红素加氧酶（HO）-1的诱导（10，37）。 HO-1通过抗氧化，抗凋亡和抗炎作用在体内和体外赋予抗氧化应激的保护作用（26，27）。通过基因转移将HO-1外源给药到大鼠肺中，可在肺中发挥有效的抗炎作用（27）。此外，HO-1的过度表达会减少粘附分子的表达，并防止随后的白细胞-内皮细胞相互作用和器官损伤（32、38）。

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《American Journal of Physiology》 |2008年第2期|共7页
作者
Jun-Te Hsu; Wen-Hong Kan; Chi-Hsun Hsieh; Mashkoor A. Choudhry; Martin G. Schwacha;
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正文语种 eng
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History of (present illness); mitogen-activated protein kinase p38; protect; 离子;

机译：（现病史）;促分裂原活化蛋白激酶p38;保护;离子;

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1. Gender differences in trauma theory vs. practice: Comments on "Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1" by Hsu JT et al. [J] . Kenneth G. Proctor American Journal of Physiology . 2008,第6aPta2期

机译：创伤理论与实践中的性别差异：Hsu JT等人评论“创伤性出血后雌激素介导的肠道保护机制：HO-1的p38 MAPK依赖性上调”。
2. Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1 [J] . Jun Te Hsu, Wen Hong Kan, Chi Hsun Hsieh, American Journal of Physiology . 2008,第6aPta2期

机译：创伤性出血后雌激素介导的肠道保护机制：HO-1的p38 MAPK依赖性上调
3. Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1 [J] . Jun-Te Hsu, Wen-Hong Kan, Chi-Hsun Hsieh, American Journal of Physiology . 2008,第6aPta2期

机译：创伤性出血后雌激素介导的肠道保护机制：HO-1的p38 MAPK依赖性上调
4. Capsaicin Induced the Upregulation of Transcriptional and Translational Expression of Glycolytic Enzymes Related to Energy Metabolism in Human Intestinal Epithelial Cells [C] . Junkyu Han, Hiroko Isoda Annual and International Meeting of the Japanese Association for Animal Cell Technology . 2010

机译：辣椒素诱导人肠上皮细胞中能量代谢相关的糖酵解酶的转录和平移表达的上调
5. Mechanisms underlying upregulation of intestinal apical chloride/hydroxyl radical exchange activity by LPA. [D] . Singla, Amika. 2010

机译：LPA上调肠顶端氯离子/羟自由基交换活性的潜在机制。
6. Bioactive Phospholipids Enhance Migration and Adhesion of Human Leukemic Cells by Inhibiting Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS) in a p38 MAPK-Dependent Manner [O] . Ahmed Abdelbaset-Ismail, Monika Cymer, Sylwia Borkowska-Rzeszotek, -1

机译：生物活性磷脂通过抑制血红素加氧酶1（HO-1）和诱导型一氧化氮合酶（iNOS）增强p38 MAPK依赖性的人类白血病细胞迁移和粘附。
7. Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-β-dependent HO-1 [O] . Huang-Ping Yu, Mashkoor A. Choudhry, Tomoharu Shimizu, 2005

机译：氟胺对创伤出血后肠道髓氧化酶活性的氟胺效应的机制：雌激素受体-β取决于HO-1的上调

Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1

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