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Differential effects of maternal nutrient restriction through pregnancy on kidney development and later blood pressure control in the resulting offspring

机译:孕期限制母体营养对子代肾脏发育和后来血压控制的不同作用

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摘要

The mechanisms whereby maternal nutritional manipulation through pregnancy result in altered blood pressure in the offspring may include changes in fetal and newborn and adult renal prostaglandin (PG) synthesis, metabolism, and receptor expression. Since the postnatal effects of nutrient restriction on the renal PG synthesis and receptor system during nephrogenesis in conjunction with nephron numbers and blood pressure have not been evaluated in the rat, the present study examined the effect of reducing maternal food intake by 50% of ad libitum through pregnancy on young male rats.
机译:孕期孕妇进行营养管理导致后代血压改变的机制可能包括胎儿和新生儿以及成年肾前列腺素(PG)合成,代谢和受体表达的变化。由于尚未评估大鼠肾脏中营养限制对肾生成过程中肾脏PG合成和受体系统以及肾单位数量和血压的产后效应,因此本研究研究了将孕妇食物摄入量减少50%的影响通过年轻的雄性大鼠怀孕。

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